Author | Queiroz, Conceição | |
Author | Silva, Tânia Maria Correia | |
Author | Alves, Venâncio Avancini Ferreira | |
Author | Villa, Luisa L. | |
Author | Costa, Maria Cecília | |
Author | Travassos, Ana Gabriela Álvares | |
Author | Araújo Filho, José Bouzas | |
Author | Studart, Eduardo | |
Author | Cheto, Tatiana | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Access date | 2014-06-12T14:04:19Z | |
Available date | 2014-06-12T14:04:19Z | |
Document date | 2006 | |
Citation | QUEIROZ, C. et al. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathology Research Practice, v. 202, n. 2, p. 77-83, 2006. | pt_BR |
ISSN | 0344-0338 | |
URI | https://www.arca.fiocruz.br/handle/icict/7818 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.prp.2005.08.012 | |
Abstract | An immunohistochemical analysis with monoclonal antibody p16INK4a was performed in formalin-fixed, paraffinembedded
samples of 60 cases. The aim was to investigate in biopsies the expression of p16INK4a of normal uterine
cervical tissue, pre-cancerous and cancerous lesions, and their relation with human papilloma virus (HPV) and HIV
status. Three parameters were evaluated: percentage of p16INK4a positive cells, reaction intensity, and cell staining
pattern. All of these parameters were statistically different when compared among different histological groups.
However, logistic regression model showed that the reaction intensity was the best indicator of the expression of
p16INK4a. This expression increases from normal to invasive squamous carcinoma. Sixty-six percent of the patients
with CIN grade 1 (CIN1) expressed p16INK4a (all these cases were infected with high risk HPV). Our study supports the
hypothesis that p16INK4a expression in pre-cancerous lesions and cancers can be used to identify HPV-transformed
cells. Of great interest for routine diagnostic use is the fact that immunohistochemical testing for p16INK4a seems to be
capable of identifying HPV-positive cells and potentially recognizing those lesions with an increased risk of progression
to high-grade lesions | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University São Paulo. Department of Pathology. Adolfo Lutz Institute. São Paulo, SP, Brasil | pt_BR |
Affilliation | Virology Department. Ludwig Institute for Cancer Research. Sao Paulo, SP, Brasil | pt_BR |
Affilliation | Virology Department. Ludwig Institute for Cancer Research. Sao Paulo, SP, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Cervical neoplasia | pt_BR |
Subject | Diagnostic marker | pt_BR |
Subject | p16INK4a | pt_BR |
Subject | Human papillomavirus; Human immunodeficiency virus | pt_BR |
DeCS | Neoplasia Intraepitelial Cervical/diagnóstico | pt_BR |
DeCS | Inibidor p16 de Quinase Ciclina-Dependente/metabolismo | pt_BR |
DeCS | Lesões Pré-Cancerosas/diagnóstico | pt_BR |
DeCS | Marcadores Biológicos de Tumor/análise | pt_BR |
DeCS | Neoplasias do Colo do Útero/diagnóstico | pt_BR |
DeCS | Carcinoma/diagnóstico | pt_BR |
DeCS | Neoplasia Intraepitelial Cervical/complicações | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Colo do Útero/metabolismo | pt_BR |
DeCS | Infecções por HIV/complicações | pt_BR |
DeCS | Infecções por HIV/diagnóstico | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Infecções por Papillomavirus/complicações | pt_BR |
DeCS | Infecções por Papillomavirus/diagnóstico | pt_BR |
DeCS | Prognóstico | pt_BR |