Author | Queiroz, Conceição | |
Author | Silva, Tânia Maria Correia | |
Author | Alves, Venâncio Avancini Ferreira | |
Author | Villa, Luisa L. | |
Author | Costa, Maria Cecília | |
Author | Travassos, Ana Gabriela Álvares | |
Author | Araújo Filho, José Bouzas | |
Author | Studart, Eduardo | |
Author | Cheto, Tatiana | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Access date | 2014-07-04T13:32:49Z | |
Available date | 2014-07-04T13:32:49Z | |
Document date | 2006 | |
Citation | QUEIROZ, C. et al. P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions. Pathology Research Practice, v. 202, n. 2, p. 731-737, 2006. | pt_BR |
ISSN | 0344-0338 | |
URI | https://www.arca.fiocruz.br/handle/icict/7867 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Comparative study of the expression of cellular cycle proteins in cervical intraepithelial lesions | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.prp.2006.07.003 | |
Abstract | Interaction of human papilloma virus oncoproteins E6 and E7 with cell cycle proteins leads to disturbances of the
cell cycle mechanism and subsequent alteration in the expression of some proteins, such as p16INK4a, cyclin D1, p53
and KI67. In this study, we compared alterations in the expression of these proteins during several stages of intraepitelial
cervical carcinogenesis. Accordingly, an immunohistochemical study was performed on 50 cervical biopsies,
including negative cases and intraepithelial neoplasias. The expression patterns of these markers were correlated with
the histopathological diagnosis and infection with HPV. The p16INK4a, followed by Ki67, showed better correlation
with cancer progression than p53 and cyclin D1, which recommends their use in the evaluation of cervical
carcinogenesis. These monoclonal antibodies can be applied to cervical biopsy specimens to identify lesions
transformed by oncogenic HPV, separating CIN 1 (p16INK4a positive) and identifying high-grade lesions by an increase
in the cellular proliferation index (Ki67). In this way, we propose immunomarkers that can be applied in clinical
practice to separate patients who need a conservative therapeutic approach from those who require a more aggressive
treatment. | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | São Paulo Federal University. Department of Pathology. Adolfo Lutz Institute. São Paulo, SP, Brasil | pt_BR |
Affilliation | Ludwig Institute for Cancer Research. Virology Department. São Paulo, SP, Brasil | pt_BR |
Affilliation | Ludwig Institute for Cancer Research. Virology Department. São Paulo, SP, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Department of Gynecology and Obstetrics. Department of Pathology, Medical School, and Mathematics and Statistic School. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Cervical neoplasia | pt_BR |
Subject | P16INK4a | pt_BR |
Subject | Cyclin D1 | pt_BR |
Subject | Ki67 | pt_BR |
Subject | p53 | pt_BR |
DeCS | Proteínas de Ciclo Celular/metabolismo | pt_BR |
DeCS | Neoplasia Intraepitelial Cervical/metabolismo | pt_BR |
DeCS | Neoplasias do Colo do Útero/metabolismo | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Idoso de 80 Anos ou mais | pt_BR |
DeCS | Biópsia | pt_BR |
DeCS | Proliferação de Células | pt_BR |
DeCS | Neoplasia Intraepitelial Cervical/patologia | pt_BR |
DeCS | Colo do Útero/anatomia & histologia | pt_BR |
DeCS | Colo do Útero/metabolismo | pt_BR |
DeCS | Ciclina D1/metabolismo | pt_BR |
DeCS | Inibidor p16 de Quinase Ciclina-Dependente/metabolismo | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Antígeno Ki-67/metabolismo | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Marcadores Biológicos de Tumor/metabolismo | pt_BR |
DeCS | Neoplasias do Colo do Útero/patologia | pt_BR |