Author | Vargens, Cristina Castro Lima | |
Author | Grassi, Maria Fernanda Rios | |
Author | Boa-Sorte, Ney Cristian Amaral | |
Author | Pinheiro, Regina Helena Rathsam | |
Author | Gallazzi, Viviana Nilla Olavarria | |
Author | Kruschewsky, Ramon de Almeida | |
Author | Castro Filho, Bernardo Galvão | |
Access date | 2014-07-25T17:19:42Z | |
Available date | 2014-07-25T17:19:42Z | |
Document date | 2011 | |
Citation | VARGENS, C. C. L. et al. Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load. Journal of Clinical Virology, v. 52, n. 3, p. 177-180, 2011. | pt_BR |
ISSN | 1873-5967 | |
URI | https://www.arca.fiocruz.br/handle/icict/8079 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jcv.2011.07.016 | |
Abstract | BACKGROUND: A high HTLV-1 proviral load is found in HTLV-1-associated diseases, mainly HAM/TSP. However, the association between proviral load and keratoconjunctivitis sicca (KCS) has not been well established. AIM: To verify the association between KCS and HTLV-1 proviral load. STUDY DESIGN: 104 HTLV-1 infected patients (51 asymptomatic and 52 with HAM/TSP) from the HTLV reference center in Salvador, Brazil were followed from June 2008 to May 2010. Evaluation of tear secretion was performed by BUT (break-up time), Rose Bengal and Schirmer I tests. The diagnosis of KCS was based upon the presence of symptoms and when at least two of three tests were positive. HTLV-1 proviral load was determined using real-time PCR. RESULTS: The prevalence of KCS was 44.2%. KCS was more frequent among HAM/TSP patients (p = 0.022). Patients with KCS had higher proviral load (mean 134,672 ± 150,393copies/10(6) PBMC) than patients without the disease (mean 66,880 ± 109,525copies/10(6) PBMC) (p = 0.001). HTLV-1 proviral load>100,000copies/10(6) PBMC increased significantly the risk of developing KCS (OR = 4.05 and 95% CI = 1.40-11.76). After age>45 years and HAM/TSP status were excluded in stepway reward analysis, the variables PVL>100,000 (OR = 4.77 and 95% CI = 1.83-12.44) still remained statistically significant. CONCLUSION: HTLV-1 proviral loads are higher in patients with KCS and may represent a relevant biological marker of disease. | pt_BR |
Affilliation | Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. IBOPC. Salvador, BA, Brasil. | pt_BR |
Affilliation | Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil. | pt_BR |
Affilliation | Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil. | pt_BR |
Affilliation | Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. IBOPC. Salvador, BA, Brasil / Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil. | pt_BR |
Affilliation | Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde .Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Instituto Brasileiro de Oftalmologia e Prevenção da Cegueira. IBOPC. Salvador, BA, Brasil. | pt_BR |
Affilliation | Centro Integrativo e Multidisciplinar de HTLV. Escola Bahiana de Medicina e Saúde Pública. EBMSP. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Ocular lesions | pt_BR |
Subject | Keratoconjuntivitis sicca | pt_BR |
Subject | Proviral load | pt_BR |
DeCS | Infecções por HTLV-I/virologia | pt_BR |
DeCS | Vírus 1 Linfotrópico T Humano/fisiologia | pt_BR |
DeCS | Ceratoconjuntivite Seca/virologia | pt_BR |
DeCS | Provirus/fisiologia | pt_BR |
DeCS | Carga Viral | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Idoso de 80 Anos ou mais | pt_BR |
DeCS | Marcadores Biológicos | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Criança | pt_BR |
DeCS | DNA Viral/análise | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Infecções por HTLV-I/diagnóstico | pt_BR |
DeCS | Vírus 1 Linfotrópico T Humano/genética | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Ceratoconjuntivite Seca/diagnóstico | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Paraparesia Espástica Tropical/diagnóstico | pt_BR |
DeCS | Paraparesia Espástica Tropical/virologia | pt_BR |