Author | Kashima, Simone G | |
Author | Alcantara, Luiz Carlos Júnior | |
Author | Takayanagui, Osvaldo Massaiti | |
Author | Cunha, Marco Aurelio Valtas | |
Author | Castro Filho, Bernardo Galvão | |
Author | Oliveira, Maria Socorro Pombo de | |
Author | Zago, Marco Antonio | |
Author | Covas, Dimas Tadeu | |
Access date | 2014-08-04T18:08:19Z | |
Available date | 2014-08-04T18:08:19Z | |
Document date | 2006 | |
Citation | KASHIMA, S. et al. Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region. AIDS Reserach Human and Retroviruses, v. 22, n. 10, p. 953-599, 2006. | pt_BR |
ISSN | 0889-2229 | |
URI | https://www.arca.fiocruz.br/handle/icict/8123 | |
Language | eng | pt_BR |
Publisher | Mary Ann Liebert, Inc | pt_BR |
Rights | open access | pt_BR |
Title | Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region. | pt_BR |
Type | Article | pt_BR |
Abstract | We report the molecular and epidemiological characterization of 128 human T cell lymphotropic virus type
1 (HTLV-1) isolates from Brazilian patients with different clinical manifestations of the infection. Thirty-two
percent of the patients were asymptomatic, 44% had HTLV-1-associated myelopathy/tropical spastic paraparesis
(HAM/TSP), and 23% had adult T cell leukemia/lymphoma (ATLL). Phylogenetic analysis performed
using part of the LTR region of the viral genome revealed that all Brazilian isolates belonged to the Cosmopolitan
subtype, with the following distribution within the Transcontinental subgroup: 81.6% within the
Latin American cluster and 15.8% outside the Latin American cluster. Two isolates belonged to the Japanese
subgroup. Molecular analysis of the tax region showed a high nucleotide similarity ( 99%) with 41 prototype
sequences, including the ATK-1 isolate. The mean number of nucleotide substitutions ranged from 1
to 8. Five specific nucleotide substitutions, C7401T, T7914C, C7920T, C7982T, and G8231A, were highly conserved
among the Brazilian isolates (79.6%), with a frequency ranging from 81.6% to 100% in the sample
group and from 18.4% to 24.1% in the prototypes used, suggesting the existence of a molecular signature.
These changes were not correlated with a specific clinical status of the patients and could be a molecular characteristic
of the HTLV-1 strains that circulate in Brazil. | pt_BR |
Affilliation | Molecular Biology Laboratory. Regional Blood Center of Ribeirão Preto. Ribeirão Preto SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade de São Paulo. Departamento de Neurologia. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | Bioinformatic Laboratory. Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Instituto Nacional do Cancer. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil | pt_BR |
DeCS | Genes pX/genética | pt_BR |
DeCS | Vírus 1 Linfotrópico T Humano/genética | pt_BR |
DeCS | Sequências Repetidas Terminais/genética | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Brasil/epidemiologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Infecções por HTLV-I/epidemiologia | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Epidemiologia Molecular | pt_BR |
DeCS | Dados de Sequência Molecular | pt_BR |