Author | Freire, Ivna Vidal | |
Author | Machado, Marco | |
Author | Ribeiro, Ícaro José Santos | |
Author | Hackney, Anthony C | |
Author | Barbosa, Ana Angélica Leal | |
Author | Pereira, Rafael | |
Access date | 2014-08-08T19:24:28Z | |
Available date | 2014-08-08T19:24:28Z | |
Document date | 2014 | |
Citation | FREIRE, I. V. et al. The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises. Journal of the Renin-Angiotensin-Aldosterone System, 2014. | pt_BR |
ISSN | 1470-3203, | |
URI | https://www.arca.fiocruz.br/handle/icict/8158 | |
Language | eng | pt_BR |
Publisher | Sage Publications | pt_BR |
Rights | open access | pt_BR |
Title | The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises | pt_BR |
Type | Article | pt_BR |
DOI | 10.1177/1470320314540733 | |
Abstract | Hypothesis/introduction: The association of ACE I/D polymorphism and hemodynamic response to exercise have
been limited to primarily aerobic exercises. We hypothesized that D allele carriers would show greater hemodynamic
response to resistance exercise, as has been observed with aerobic. This study aimed to investigate the association
of ACE I/D polymorphism and hemodynamic (blood pressure (BP), heart rate (HR) and rate-pressure product (RPP))
response to resistance exercise in young healthy subjects.
Materials and methods: ACE I/D polymorphisms were studied by PCR analysis from 75 healthy men. Subjects
completed a resistance exercise session of three sets of 10 knee extension repetitions with loads of 50, 75 and 100%
of 10RM and two-minute rest intervals. Hemodynamic measures were recorded before and immediately after each set.
Analysis of variance was used to identify significant differences among ACE genotypes.
Results: ACE I/D polymorphism is associated with hemodynamic response to resistance exercise, as healthy subjects
with ACE D allele were prone to higher responses. In addition, this phenotypic difference seems to be a load-dependent
trend.
Conclusion: ACE DD carriers exhibit greater heart work during resistance exercise. Future studies should focus on
the influence of resistance training period with different workloads on the hemodynamic response in healthy individuals
with different ACE genotypes. | pt_BR |
Affilliation | State University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, Brasil | pt_BR |
Affilliation | Universitary Fundation of Itaperuna. Laboratory of Human Movement Studies. Itaperuna, RJ, Brasil / Universidade Iguaçu Itaperuna. Laboratory of Physiology and Biokinetics. Itaperuna, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | University of North Carolina. Endocrine Section. Applied Physiology Laboratory. Chapel Hill, USA | pt_BR |
Affilliation | State University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, Brasil | pt_BR |
Affilliation | State University of Southwest Bahia. Human Genetics Laboratory. Department of Biological Sciences. Salvador, BA, Brasil | pt_BR |
Subject | Renin-angiotensin system | pt_BR |
Subject | Candidate gene | pt_BR |
Subject | ACE I/D polymorphism | pt_BR |
Subject | Exercise | pt_BR |
Subject | Blood pressure | pt_BR |