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https://www.arca.fiocruz.br/handle/icict/8222
COASSOCIATIONS BETWEEN IL10 POLYMORPHISMS, IL-10 PRODUCTION, HELMINTH INFECTION, AND ASTHMA/WHEEZE IN AN URBAN TROPICAL POPULATION IN BRAZIL.
Polymorphisms
Helminth infection
Immune modulation
Allergy
Asthma
Social changes asthma and allergy in Latin America
Asma/etiologia
Helmintíase/complicações
Interleucina-10/biossíntese
Polimorfismo Genético
Sons Respiratórios/etiologia
Adolescente
Alelos
Brasil/epidemiologia
Criança
Pré-Escolar
Feminino
Ligação Genética
Genótipo
Humanos
Lactente
Desequilíbrio de Ligação
Masculino
Polimorfismo de Nucleotídeo Único
População Urbana
Autor(es)
Figueiredo, Camila Alexandrina Viana
Barreto, Maurício Lima
Neves, Neuza Maria Alcântara
Rodrigues, Laura Cunha
Cooper, Philip John
Cruz Filho, Alvaro Augusto Souza da
Pontes-de-Carvalho, Lain Carlos
Lemaire, Denise Carneiro
Costa, Ryan dos Santos
Amorim, Leila D
Vergara, Candelaria
Rafaels, Nicholas
Gao, Li
Foster, Cassandra
Campbell, Monica
Mathias, Rasika A
Barnes, Kathleen C
Barreto, Maurício Lima
Neves, Neuza Maria Alcântara
Rodrigues, Laura Cunha
Cooper, Philip John
Cruz Filho, Alvaro Augusto Souza da
Pontes-de-Carvalho, Lain Carlos
Lemaire, Denise Carneiro
Costa, Ryan dos Santos
Amorim, Leila D
Vergara, Candelaria
Rafaels, Nicholas
Gao, Li
Foster, Cassandra
Campbell, Monica
Mathias, Rasika A
Barnes, Kathleen C
Afiliação
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA / Instituto de Ciências da Saúde. Salvador, BA, Brasil
Instituto de Sa ude Coletiva. Salvador, BA, Brasil
Instituto de Ciências da Saúde. Salvador, BA, Brasil
London School of Hygiene and Tropical Medicine. London, USA
Universidad San Francisco de Quito. Ecuador, Quito / University of London. Centre for Infection St George’s. London, USA
ProAR–N ucleo de Excelência em Asma. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Instituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil
Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matem atica. Salvador, BA, Brasil
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Instituto de Sa ude Coletiva. Salvador, BA, Brasil
Instituto de Ciências da Saúde. Salvador, BA, Brasil
London School of Hygiene and Tropical Medicine. London, USA
Universidad San Francisco de Quito. Ecuador, Quito / University of London. Centre for Infection St George’s. London, USA
ProAR–N ucleo de Excelência em Asma. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Instituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil
Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matem atica. Salvador, BA, Brasil
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA
Resumo em Inglês
BACKGROUND: Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG4 production, protecting against allergies. OBJECTIVE: We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy. METHODS: Twelve IL10 single nucleotide polymorphisms were genotyped in 1353 children aged 4 to 11 years living in a poor urban area in Salvador, Brazil. Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection, IL-10 production by peripheral blood leukocytes stimulated with A lumbricoides extract, serum total IgE levels, specific IgE levels, skin prick test responses to common aeroallergens, and IgG4 and IgE anti-A lumbricoides antibody levels were measured in all children. Association tests were performed by using logistic or linear regression when appropriate, including sex, age, helminth infection, and principal components for ancestry informative markers as covariates by using PLINK. RESULTS: Allele G of marker rs3024496 was associated with the decreased production of IL-10 by peripheral blood leukocytes in response to A lumbricoides stimulation. Allele C of marker rs3024498 was negatively associated with helminth infection or its markers. Marker rs3024492 was positively associated with the risk of atopic wheeze, total IgE levels, and skin prick test responses to cockroach. CONCLUSIONS: Our findings suggest that IL10 polymorphisms might play a role in the production of IL-10, helminth infection, and allergy. We hypothesize that polymorphisms related to protection against helminths, which would offer an evolutionary advantage to subjects in the past, might be associated with increased risk of allergic diseases.
Palavras-chave em inglês
IL10Polymorphisms
Helminth infection
Immune modulation
Allergy
Asthma
Social changes asthma and allergy in Latin America
DeCS
Asma/epidemiologiaAsma/etiologia
Helmintíase/complicações
Interleucina-10/biossíntese
Polimorfismo Genético
Sons Respiratórios/etiologia
Adolescente
Alelos
Brasil/epidemiologia
Criança
Pré-Escolar
Feminino
Ligação Genética
Genótipo
Humanos
Lactente
Desequilíbrio de Ligação
Masculino
Polimorfismo de Nucleotídeo Único
População Urbana
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