Author | Rogers, Kathleen A | |
Author | DeKrey, Gregory K | |
Author | Mbow, M. Lamine | |
Author | Gillespie, R. Dean | |
Author | Brodskyn, Claudia Ida | |
Author | Titus, Richard G | |
Access date | 2014-09-19T13:16:20Z | |
Available date | 2014-09-19T13:16:20Z | |
Document date | 2002 | |
Citation | ROGERS, K. A. et al. Type 1 and type 2 responses to Leishmania major. FEMS Microbiology Letters, v. 209, n. 1, p. 1-7, 2002. | pt_BR |
ISSN | 0378-1097 | |
URI | https://www.arca.fiocruz.br/handle/icict/8402 | |
Language | eng | pt_BR |
Publisher | Elsevier Science B.V | pt_BR |
Rights | open access | pt_BR |
Title | Type 1 and type 2 responses to Leishmania major | pt_BR |
Type | Article | pt_BR |
Abstract | Leishmania major is a protozoan parasite that is transmitted to the mammalian host by its sand fly vector when the fly probes in the
host's skin for a blood meal and injects the parasite within its saliva. In mice experimentally infected with L. major, outgrowth of CD4
type 1 (Th1) cells leads to resolution of the infection, but outgrowth of type 2 (Th2) cells exacerbates disease. To design an effective
vaccine against the parasite (and other pathogens that induce polarized Th1 and Th2 responses), we must determine the mechanism
underlying this phenomenon so that we can design the vaccine to elicit the appropriate (i.e., protective) Th cell. Recent work indicates that
Th bias is influenced by a number of signals delivered by antigen-presenting cells, including cytokines and co-stimulatory molecules.
Moreover, recent work also suggests that sand fly saliva influences the immune response to L. major and Th polarization. Determining the
mechanisms that lead to polarized Th responses should expand our knowledge regarding immunity to L. major, and should add to our
understanding of immunoregulation in general | pt_BR |
Affilliation | University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado | pt_BR |
Affilliation | University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado | pt_BR |
Affilliation | Biopharmaceutical Research, Centocor. Malvern, PA, USA | pt_BR |
Affilliation | Colorado State University. College of Veterinary Medicine and Biomedical Sciences. Department of Microbiology, Immunology and Pathology. CO, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Th cell | pt_BR |
Subject | Antigen-presenting cell | pt_BR |
Subject | Cytokine | pt_BR |
Subject | Co-stimulation | pt_BR |
Subject | Sand fly | pt_BR |
DeCS | Leishmania major/imunologia | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Células Th1/imunologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Apresentação do Antígeno | pt_BR |
DeCS | Antígenos CD/imunologia | pt_BR |
DeCS | Suscetibilidade a Doenças | pt_BR |
DeCS | Previsões | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Proteínas de Insetos/imunologia | pt_BR |
DeCS | Insetos Vetores/parasitologia | pt_BR |
DeCS | Leishmaniose Cutânea/transmissão | pt_BR |
DeCS | Ativação Linfocitária | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos | pt_BR |
DeCS | Vacinas Protozoárias/imunologia | pt_BR |
DeCS | Psychodidae/imunologia | pt_BR |
DeCS | Saliva/parasitologia | pt_BR |
DeCS | Proteínas e Peptídeos Salivares/imunologia | pt_BR |
DeCS | Células Th1/secreção | pt_BR |