Author | Juneja, Annu | |
Author | Macedo, Taís Soares | |
Author | Moreira, Diogo Rodrigo Magalhães | |
Author | Soares, Milena Botelho Pereira | |
Author | Leite, Ana Cristina Lima | |
Author | Neves, Juliana Kelle de Andrade Lemoine | |
Author | Pereira, Valéria Rêgo Alves | |
Author | Avecilla, Fernando | |
Author | Azam, Amir | |
Access date | 2014-09-26T16:29:40Z | |
Available date | 2014-09-26T16:29:40Z | |
Document date | 2014 | |
Citation | JUNEJA, A. et al. Synthesis of 4'-(2-ferrocenyl)-2,2':6'2''-terpyridine: characterization and antiprotozoal activity of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes. European Journal of Medicinal Chemistry, v. 75, p. 203-210, 2014. | pt_BR |
ISSN | 1768-3254 | |
URI | https://www.arca.fiocruz.br/handle/icict/8458 | |
Language | eng | pt_BR |
Publisher | Elsevier Masson SAS | pt_BR |
Rights | open access | pt_BR |
Title | Synthesis of 4'-(2-ferrocenyl)-2,2':6'2''-terpyridine: characterization and antiprotozoal activity of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ejmech.2014.01.051 | |
Abstract | A terpyridine ligand Fctpy was reacted with divalent metals (Cu, Co, Mn, Ni and Zn), yielding five complexes of general formula [Metal(Fctpy)2][PF6]2. The structure of Fctpy was determined by single crystal X-ray diffraction studies. The complexes characterized using various spectroscopic techniques suggested an octahedral geometry around the central metal ion. These complexes were screened for their antiamoebic, trypanocidal and antimalarial activities. It was found that, complexes 2 and 3 showed better IC50 values than metronidazole against HM1:IMSS strain of Entamoeba histolytica. A substantial parasitic inhibition was not observed for the trypanocidal activity. However, for the erythrocytic stage of W2 strain of Plasmodium falciparum, the complexes inhibited ß-hematin formation. At the concentration of 10 µg/mL, these complexes did not display toxicity. | pt_BR |
Affilliation | Jamia Millia Islamia. Jamia Nagar. Department of Chemistry. New Delhi, India | |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | |
Affilliation | Federal University of Pernambuco. Centre for Health Sciences. Department of Pharmaceutical Sciences. Recife, PE, Brazil | |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil | |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil | |
Affilliation | Universidade da Coruña. Departamento de Química Fundamental. Coruña, Spain | |
Affilliation | Jamia Millia Islamia. Jamia Nagar. Department of Chemistry. New Delhi, India | |
Subject | Metal complexes | pt_BR |
Subject | Terpyridine | pt_BR |
Subject | Ferrocenyl | pt_BR |
Subject | Amoebiasis | pt_BR |
Subject | Malaria | pt_BR |