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https://www.arca.fiocruz.br/handle/icict/8463
MOLECULAR EPIDEMIOLOGY AND CLINICAL FEATURES OF HUMAN T CELL LYMPHOTROPIC VIRUS TYPE 1 INFECTION IN SPAIN
Relações sexuais
Masculino
Feminino
Adulto
Mielopatia associada ao HTLV-I
Leucemia
Linfoma de células
Autor(es)
Trevinõ, Ana
Alcantara, Luiz Carlos Júnior
Benito, Rafael
Caballero, Estrella
Aguilera, Antonio
Ramos, José Manuel
Mendoza, Carmen de
Rodríguez, Carmen
García, Juan
Iglesias, Manuel Rodrguez
Lejarazu, Raúl Ortiz de
Roc, Lourdes
Parra, Patricia
Eiros, José
del Romero, Jorge
Soriano, Vincent
HTLV Spanish Study Group
Alcantara, Luiz Carlos Júnior
Benito, Rafael
Caballero, Estrella
Aguilera, Antonio
Ramos, José Manuel
Mendoza, Carmen de
Rodríguez, Carmen
García, Juan
Iglesias, Manuel Rodrguez
Lejarazu, Raúl Ortiz de
Roc, Lourdes
Parra, Patricia
Eiros, José
del Romero, Jorge
Soriano, Vincent
HTLV Spanish Study Group
Afiliação
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Hospital Clínico Universitario Lozano Blesa. Service of Microbiology. Zaragoza, Spain
Hospital Vall d’Hebron. Service of Microbiology. Barcelona, Spain
Hospital Conxo-CHUS. Service of Microbiology. Santiago, Spain
Hospital General de Elche. Infectious Disease Unit. Elche, Spain
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
Centro Sanitario Sandoval. Madrid, Spain
Hospital Cristal-Piñor. Service of Microbiology. Orense, Spain
Hospital Universitario Puerta del Mar. Service of Microbiology. Cádiz, Spain
Hospital Clínico Universitario. Service of Microbiology. Valladolid, Spain
Hospital Miguel Servet. Service of Microbiology. Zaragoza, Spain
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
Hospital Clínico Universitario. Service of Microbiology. Valladolid, Spain
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
HTLV Spanish Study Group
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Hospital Clínico Universitario Lozano Blesa. Service of Microbiology. Zaragoza, Spain
Hospital Vall d’Hebron. Service of Microbiology. Barcelona, Spain
Hospital Conxo-CHUS. Service of Microbiology. Santiago, Spain
Hospital General de Elche. Infectious Disease Unit. Elche, Spain
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
Centro Sanitario Sandoval. Madrid, Spain
Hospital Cristal-Piñor. Service of Microbiology. Orense, Spain
Hospital Universitario Puerta del Mar. Service of Microbiology. Cádiz, Spain
Hospital Clínico Universitario. Service of Microbiology. Valladolid, Spain
Hospital Miguel Servet. Service of Microbiology. Zaragoza, Spain
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
Hospital Clínico Universitario. Service of Microbiology. Valladolid, Spain
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
Hospital Carlos III. Infectious Diseases Department. Madrid, Spain
HTLV Spanish Study Group
Resumo em Inglês
Human T cell lymphotropic virus type 1 (HTLV-1) infection in Spain is rare and mainly affects immigrants
from endemic regions and native Spaniards with a prior history of sexual intercourse with persons from endemic
countries. Herein, we report the main clinical and virological features of cases reported in Spain. All individuals
with HTLV-1 infection recorded at the national registry since 1989 were examined. Phylogenetic analysis was
performed based on the long terminal repeat (LTR) region. A total of 229 HTLV-1 cases had been reported up
to December 2012. The mean age was 41 years old and 61% were female. Their country of origin was Latin
America in 59%, Africa in 15%, and Spain in 20%. Transmission had occurred following sexual contact in
41%, parenteral exposure in 12%, and vertically in 9%. HTLV-1-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) was diagnosed in 27 cases and adult T cell leukemia/lymphoma (ATLL) in 17 subjects.
HTLV-1 subtype could be obtained for 45 patients; all but one belonged to the Cosmopolitan subtype a. One
Nigerian pregnant woman harbored HTLV-1 subtype b. Within the Cosmopolitan subtype a, two individuals
(from Bolivia and Peru, respectively) belonged to the Japanese subgroup B, another two (from Senegal and
Mauritania) to the North African subgroup D, and 39 to the Transcontinental subgroup A. Of note, one
divergent HTLV-1 strain from an Ethiopian branched off from all five known Cosmopolitan subtype 1a
subgroups. Divergent HTLV-1 strains have been introduced and currently circulate in Spain. The relatively
large proportion of symptomatic cases (19%) suggests that HTLV-1 infection is underdiagnosed in Spain.
Palavras-chave
HTLV-IRelações sexuais
Masculino
Feminino
Adulto
Mielopatia associada ao HTLV-I
Leucemia
Linfoma de células
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