Author | Luz, Ricardo Alves | pt_BR |
Author | Xavier-Elsas, Pedro Paulo | pt_BR |
Author | Luca, Bianca de | pt_BR |
Author | Masid-de-Brito, Daniela | pt_BR |
Author | Cauduro, Priscila Soares | pt_BR |
Author | Arcanjo, Luiz Carlos Gondar | pt_BR |
Author | Santos, Ana Carolina Cordeiro Faria dos | pt_BR |
Author | Oliveira, Ivi Cristina Maria de | pt_BR |
Author | Gaspar-Elsas, Maria Ignez Capella | pt_BR |
Access date | 2014-11-06T17:31:55Z | |
Available date | 2014-11-06T17:31:55Z | |
Document date | 2014 | pt_BR |
Citation | LUZ, Ricardo Alves. et al. 5-Lipoxygenase-dependent recruitment of neutrophils and macrophages by eotaxin-stimulated murine eosinophils. Mediat. inflamm.,New York, 2014. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/8745 | |
Language | eng | pt_BR |
Publisher | Hindawi Publishing Corporation | pt_BR |
Rights | open access | pt_BR |
Title | 5-Lipoxygenase-dependent recruitment of neutrophils and macrophages by eotaxin-stimulated murine eosinophils | pt_BR |
Type | Article | pt_BR |
DOI | 10.1155/2014/102160 | pt_BR |
Abstract | The roles of eosinophils in antimicrobial defense remain incompletely understood. In ovalbumin-sensitized mice, eosinophils are
selectively recruited to the peritoneal cavity by antigen, eotaxin, or leukotriene(LT)B4, a 5-lipoxygenase (5-LO) metabolite. 5-LO
blockade prevents responses to both antigen and eotaxin.We examined responses to eotaxin in the absence of sensitization and their
dependence on 5-LO. BALB/c or PAS mice and their mutants (5-LO-deficient ALOX; eosinophil-deficient GATA-1) were injected
i.p. with eotaxin, eosinophils, or both, and leukocyte accumulation was quantified up to 24 h. Significant recruitment of eosinophils
by eotaxin in BALB/c, up to 24 h, was accompanied bymuch larger numbers of recruited neutrophils andmonocytes/macrophages.
These effects were abolished by eotaxin neutralization and 5-LO-activating protein inhibitor MK886. In ALOX (but not PAS)
mice, eotaxin recruitment was abolished for eosinophils and halved for neutrophils. In GATA-1 mutants, eotaxin recruited neither
neutrophils nor macrophages. Transfer of eosinophils cultured from bone-marrow of BALB/c donors, or from ALOX donors, into
GATA-1 mutant recipients, i.p., restored eotaxin recruitment of neutrophils and showed that the critical step dependent on 5-LO is
the initial recruitment of eosinophils by eotaxin, not the secondary neutrophil accumulation. Eosinophil-dependent recruitment
of neutrophils in naive BALB/c mice was associated with increased binding of bacteria. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. / Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Puericultura e Pediatria Martagão Gesteira. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Puericultura e Pediatria Martagão Gesteira. Departamento de Microbiologia Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
DeCS | Eosinófilos | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Antígenos | pt_BR |
DeCS | Neutrófilos | pt_BR |
DeCS | Medula Óssea | pt_BR |