Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/8758
Tipo de documento
ArtigoDireito Autoral
Acesso aberto
Data de embargo
2014-11-29
Coleções
- IFF - Artigos de Periódicos [1263]
- IOC - Artigos de Periódicos [12488]
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ACTIN CYTOSKELETON CONTROL OF THE COMINGS AND GOINGS OF T LYMPHOCYTES
Afiliação
INSERM. U1043. Toulouse, France / Université Toulouse III Paul-Sabatier. Centre de Physiopathologie de Toulouse Purpan. Toulouse, France / CNRS. U5282. Toulouse, France.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Thymus. Rio de Janeiro, RJ, Brasil.
INSERM. U1043. Toulouse, France / Université Toulouse III Paul-Sabatier. Centre de Physiopathologie de Toulouse Purpan. Toulouse, France / CNRS. U5282. Toulouse, France.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Thymus. Rio de Janeiro, RJ, Brasil.
INSERM. U1043. Toulouse, France / Université Toulouse III Paul-Sabatier. Centre de Physiopathologie de Toulouse Purpan. Toulouse, France / CNRS. U5282. Toulouse, France.
Resumo em Inglês
T lymphocytes are key players of adaptive immune responses. Upon recognition of
specific peptides presented by human leukocyte antigen (HLA) molecules on antigen
presenting cells (APC), these cells execute subset-related functions such as killing,
help and regulation. The ontogeny, the activation and the effector functions of T
lymphocytes are all steps of T-lymphocyte life cycle that rely on high motility
properties. These cells travel through the organism in a succession of steps, including
entry into tissues, interstitial migration, APC scanning, synapse formation and tissue
exit. Such ability is possible because of a plastic motility behavior, which is highly
controlled in time and space. The molecular basis for the adaptable motility behavior
of T lymphocytes is only starting to be unraveled. The scope of this review is
to discuss recent data pointing to the key role of regulators of actin cytoskeleton
remodeling in tuning distinct aspects of T-lymphocyte motility during their entry,
residency and exit from tissues.
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