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THE ROLE OF CD4 AND CD8 T CELLS IN HUMAN CUTANEOUS LEISHMANIASIS.
Human adaptive immunology
Cutaneous leishmaniasis
CD4 and CD8 T cells
Leishmania braziliensis
Immune response
Afiliación
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil
Resumen en ingles
Leishmaniasis, caused by infection with parasites of the Leishmania genus, affects millions
of individuals worldwide.This disease displays distinct clinical manifestations ranging from
self-healing skin lesions to severe tissue damage. The control of Leishmania infection is
dependent on cellular immune mechanisms, and evidence has shown that CD4 and CD8T
lymphocytes play different roles in the outcome of leishmaniasis. Although the presence of
CD4T cells is important for controlling parasite growth, the results in the literature suggest
that the inflammatory response elicited by these cells could contribute to the pathogenesis
of lesions. However, recent studies on CD8 T lymphocytes show that these cells are
mainly involved in tissue damage through cytotoxic mechanisms. In this review, we focus
on the recent advances in the study of the human adaptive immunological response in the
pathogenesis of tegumentary leishmaniasis.
Palabras clave en ingles
Adaptive immunityHuman adaptive immunology
Cutaneous leishmaniasis
CD4 and CD8 T cells
Leishmania braziliensis
Immune response
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