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Autor | Santos, Claire da Silva | |
Autor | Brodskyn, Claudia Ida | |
Fecha de acceso | 2014-11-12T19:35:15Z | |
Fecha de disponibilización | 2014-11-12T19:35:15Z | |
Fecha de publicación | 2014 | |
Referencia | SANTOS, C. S.; BRODSKYN, C. I. The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis. Frontiers Public Health, v. 2, p.165, 2014. | pt_BR |
ISSN | 2296-2565 | |
URI | https://www.arca.fiocruz.br/handle/icict/8819 | |
Idioma | eng | pt_BR |
Editor | Frontiers | pt_BR |
Derechos de autor | open access | pt_BR |
Título | The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis. | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.3389/fpubh.2014.00165 | |
Resumen en Inglés | Leishmaniasis, caused by infection with parasites of the Leishmania genus, affects millions of individuals worldwide.This disease displays distinct clinical manifestations ranging from self-healing skin lesions to severe tissue damage. The control of Leishmania infection is dependent on cellular immune mechanisms, and evidence has shown that CD4 and CD8T lymphocytes play different roles in the outcome of leishmaniasis. Although the presence of CD4T cells is important for controlling parasite growth, the results in the literature suggest that the inflammatory response elicited by these cells could contribute to the pathogenesis of lesions. However, recent studies on CD8 T lymphocytes show that these cells are mainly involved in tissue damage through cytotoxic mechanisms. In this review, we focus on the recent advances in the study of the human adaptive immunological response in the pathogenesis of tegumentary leishmaniasis. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil | pt_BR |
Palavras clave en Inglês | Adaptive immunity | pt_BR |
Palavras clave en Inglês | Human adaptive immunology | pt_BR |
Palavras clave en Inglês | Cutaneous leishmaniasis | pt_BR |
Palavras clave en Inglês | CD4 and CD8 T cells | pt_BR |
Palavras clave en Inglês | Leishmania braziliensis | pt_BR |
Palavras clave en Inglês | Immune response | pt_BR |