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https://www.arca.fiocruz.br/handle/icict/8838
PALMITOYLATION AND P8-MEDIATED HUMAN T-CELL LEUKEMIA VIRUS TYPE 1 TRANSMISSION.
Vírus 1 Linfotrópico T Humano/genética
Lipoilação/fisiologia
Proteínas Virais Reguladoras e Acessórias/genética
Sequência de Aminoácidos
Primers do DNA/genética
Dimerização
Células HEK293
Vírus 1 Linfotrópico T Humano/fisiologia
Humanos
Immunoblotting
Imunoprecipitação
Dados de Sequência Molecular
Mutagênese
Mutação de Sentido Incorreto
Subunidades Proteicas/metabolismo
Transporte Proteico
Proteínas Virais Reguladoras e Acessórias/química
Autor(es)
Afiliação
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
National Institutes of Health. National Cancer Institute. Animal Models and Retroviral Vaccines Section. Center for Cancer Research. Bethesda, MD, USA
Resumo em Inglês
The orf-I gene of human T-cell leukemia type 1 (HTLV-1) encodes p8 and p12 and has a conserved cysteine at position 39. p8 and
p12 form disulfide-linked dimers, and only the monomeric forms of p8 and p12 are palmitoylated. Mutation of cysteine 39 to
alanine (C39A) abrogated dimerization and palmitoylation of both proteins. However, the ability of p8 to localize to the cell surface
and to increase cell adhesion and viral transmission was not affected by the C39A mutation.
DeCS
Infecções por HTLV-I/transmissãoVírus 1 Linfotrópico T Humano/genética
Lipoilação/fisiologia
Proteínas Virais Reguladoras e Acessórias/genética
Sequência de Aminoácidos
Primers do DNA/genética
Dimerização
Células HEK293
Vírus 1 Linfotrópico T Humano/fisiologia
Humanos
Immunoblotting
Imunoprecipitação
Dados de Sequência Molecular
Mutagênese
Mutação de Sentido Incorreto
Subunidades Proteicas/metabolismo
Transporte Proteico
Proteínas Virais Reguladoras e Acessórias/química
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