Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/8920
IMMUNOHISTOCHEMICAL ASSESSMENT OF CD1A-POSITIVE LANGERHANS CELLS AND THEIR RELATIONSHIP WITH E-CADHERIN IN MINOR SALIVARY GLAND TUMORS.
Caderinas/análise
Células de Langerhans/patologia
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores/patologia
Adenocarcinoma/patologia
Adenoma Pleomorfo/patologia
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/patologia
Contagem de Células
Corantes/uso diagnóstico
Células Dendríticas/patologia
Epitélio/patologia
Feminino
Humanos
Processamento de Imagem Assistida por Computador/métodos
Imuno-Histoquímica
Células de Langerhans/imunologia
Masculino
Meia-Idade
Autor(es)
Afiliação
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Aristides Maltez Hospital. Department of Pathology,. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Aristides Maltez Hospital. Department of Pathology,. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Resumo em Inglês
OBJECTIVE: The aim of this study was to investigate the presence of CD1a-positive Langerhans cells and their relationship with E-cadherin in minor salivary gland tumors. METHODS: Twenty-seven minor salivary gland tumors were investigated using immunohistochemistry for CD1a and E-cadherin. RESULTS: A significant difference regarding the mean density of CD1a-positive Langerhans cells was observed between pleomorphic adenomas and malignant tumors studied (P = 0.001). No CD1a-positive cells were detected in most cases (n = 5) of cystic adenoid carcinomas. CD1a-positive cells were detected in one mucoepidermoid carcinoma case, and six low-grade polymorphous adenocarcinomas cases. Comparison of the mean density of CD1a-positive cells between the three malignant tumors showed no significant difference (P = 0.127). No significant difference was observed in the presence of E-cadherin between tumors (P = 0.73), but it was detected in 24 cases. CONCLUSIONS: The lack of CD1a-positive in malignant salivary gland tumors facilitates the neoplastic development and suggests that these cells might be useful as auxiliary diagnostic and prognostic tool in minor salivary gland tumors. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors although we did not demonstrate significance.
DeCS
Antígenos CD1/análiseCaderinas/análise
Células de Langerhans/patologia
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores/patologia
Adenocarcinoma/patologia
Adenoma Pleomorfo/patologia
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/patologia
Contagem de Células
Corantes/uso diagnóstico
Células Dendríticas/patologia
Epitélio/patologia
Feminino
Humanos
Processamento de Imagem Assistida por Computador/métodos
Imuno-Histoquímica
Células de Langerhans/imunologia
Masculino
Meia-Idade
Compartilhar