Author | Dultra, Fátima Karoline Araújo Alves | |
Author | Barros, Adna Conceição | |
Author | Barbosa, Helenemarie Schaer | |
Author | Figueiredo, Andreia Leal | |
Author | Gurgel, Clarissa Araújo Silva | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Carvalho, Ana Maria da Silva | |
Author | Santos, Jean Nunes dos | |
Access date | 2014-11-19T17:25:38Z | |
Available date | 2014-11-19T17:25:38Z | |
Document date | 2012 | |
Citation | DULTRA, F. K. A. et al. Immunohistochemical assessment of CD1a-positive Langerhans cells and their relationship with E-cadherin in minor salivary gland tumors. Journal of Oral Pathology & Medicine, v. 41, n. 1, p. 47-53, 2012. | pt_BR |
ISSN | 1600-0714 | |
URI | https://www.arca.fiocruz.br/handle/icict/8920 | |
Language | eng | pt_BR |
Publisher | John Wiley & Sons Ltd | pt_BR |
Rights | open access | pt_BR |
Title | Immunohistochemical assessment of CD1a-positive Langerhans cells and their relationship with E-cadherin in minor salivary gland tumors. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/j.1600-0714.2011.01052.x | |
Abstract | OBJECTIVE: The aim of this study was to investigate the presence of CD1a-positive Langerhans cells and their relationship with E-cadherin in minor salivary gland tumors. METHODS: Twenty-seven minor salivary gland tumors were investigated using immunohistochemistry for CD1a and E-cadherin. RESULTS: A significant difference regarding the mean density of CD1a-positive Langerhans cells was observed between pleomorphic adenomas and malignant tumors studied (P = 0.001). No CD1a-positive cells were detected in most cases (n = 5) of cystic adenoid carcinomas. CD1a-positive cells were detected in one mucoepidermoid carcinoma case, and six low-grade polymorphous adenocarcinomas cases. Comparison of the mean density of CD1a-positive cells between the three malignant tumors showed no significant difference (P = 0.127). No significant difference was observed in the presence of E-cadherin between tumors (P = 0.73), but it was detected in 24 cases. CONCLUSIONS: The lack of CD1a-positive in malignant salivary gland tumors facilitates the neoplastic development and suggests that these cells might be useful as auxiliary diagnostic and prognostic tool in minor salivary gland tumors. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors although we did not demonstrate significance. | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
Affilliation | Aristides Maltez Hospital. Department of Pathology,. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil | pt_BR |
Subject | Cell adhesion | pt_BR |
Subject | Dendritic cell | pt_BR |
Subject | Immunohistochemistry | pt_BR |
Subject | Salivary gland tumors | pt_BR |
DeCS | Antígenos CD1/análise | pt_BR |
DeCS | Caderinas/análise | pt_BR |
DeCS | Células de Langerhans/patologia | pt_BR |
DeCS | Neoplasias das Glândulas Salivares/patologia | pt_BR |
DeCS | Glândulas Salivares Menores/patologia | pt_BR |
DeCS | Adenocarcinoma/patologia | pt_BR |
DeCS | Adenoma Pleomorfo/patologia | pt_BR |
DeCS | Carcinoma Adenoide Cístico/patologia | pt_BR |
DeCS | Carcinoma Mucoepidermoide/patologia | pt_BR |
DeCS | Contagem de Células | pt_BR |
DeCS | Corantes/uso diagnóstico | pt_BR |
DeCS | Células Dendríticas/patologia | pt_BR |
DeCS | Epitélio/patologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Processamento de Imagem Assistida por Computador/métodos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Células de Langerhans/imunologia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |