Author | Oliveira, Cristiane Metzker de | |
Author | Nonato, Fabiana Regina | |
Author | Lima, Flávia Oliveira de | |
Author | Couto, Ricardo David | |
Author | David, Juceni Pereira de Lima | |
Author | David, Jorge Mauricio | |
Author | Soares, Milena Botelho Pereira | |
Author | Villarreal, Cristiane Flora | |
Access date | 2014-11-27T19:13:52Z | |
Available date | 2014-11-27T19:13:52Z | |
Document date | 2011 | |
Citation | OLIVEIRA, C. M. et al. Antinociceptive properties of bergenin. Journal of Natural Products, v. 74, n. 10, p. 2062-2068, 2011. | pt_BR |
ISSN | 1520-6025 | |
URI | https://www.arca.fiocruz.br/handle/icict/8987 | |
Language | eng | pt_BR |
Publisher | American Chemical Society | pt_BR |
Rights | open access | pt_BR |
Title | Antinociceptive properties of bergenin | pt_BR |
Type | Article | pt_BR |
DOI | dx.doi.org/10.1021/np200232s | |
Abstract | Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with 1 (12.5-100 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with 1 (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, 1 (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-α and IL-1ß) induced by complete Freund's adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by 1 (100 mg/kg, ip). Treatment with 1 produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with 1 did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1ß and TNF-α production, and suggest its potential for the control of inflammatory pain. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
DeCS | Analgésicos/farmacologia | pt_BR |
DeCS | Anti-Inflamatórios não Esteroides/farmacologia | pt_BR |
DeCS | Benzopiranos/farmacologia | pt_BR |
DeCS | Dor/quimioterapia | pt_BR |
DeCS | Analgésicos/química | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Anti-Inflamatórios não Esteroides/química | pt_BR |
DeCS | Benzopiranos/química | pt_BR |
DeCS | Relação Dose-Resposta a Droga | pt_BR |
DeCS | Edema/induzido quimicamente | pt_BR |
DeCS | Ácido Gálico/análogos & derivados | pt_BR |
DeCS | Interleucina-10/antagonistas & inibidores | pt_BR |
DeCS | Interleucina-10/biossíntese | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Dor/induzido quimicamente | pt_BR |
DeCS | Medição da Dor | pt_BR |
DeCS | Fator de Necrose Tumoral alfa/antagonistas & inibidores | pt_BR |