Author | Hygino, Joana | |
Author | Vieira, Morgana M. | |
Author | Guillermo, Landi V. | |
Author | Silva-Filho, Renato G. | |
Author | Lima-Silva, Agostinho A. | |
Author | Andrade, Regis M. | |
Author | Andrade, Arnaldao F. B. | |
Author | Brindeiro, Rodrigo M. | |
Author | Tanuri, Amilcar | |
Author | Guimarães, Vander | |
Author | Bento, Cleonice Alves de Melo | |
Access date | 2014-12-17T13:47:36Z | |
Available date | 2014-12-17T13:47:36Z | |
Document date | 2011 | |
Citation | HYGINO, Joana. et al. Enhanced th17 phenotype in uninfected neonates born from viremic HIV-1-infected pregnant women. J. clin. immunol., New York, v. 31, p. 186–194, 2011. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/9196 | |
Language | eng | pt_BR |
Publisher | Plenum Press | pt_BR |
Rights | restricted access | pt_BR |
Title | Enhanced th17 phenotype in uninfected neonates born from viremic HIV-1-infected pregnant women | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s10875-010-9485-3 | |
Abstract | Our objective was to evaluate the in vitro
functional profile of T cells from uninfected neonates born
from HIV-1-infected pregnant women who controlled (G1)
or not (G2) the virus replication. We demonstrated that the
lymphoproliferation of T cell to polyclonal activators was
higher in the G2 as compared with G1. Nevertheless, no
detectable proliferative response was observed in response
to HIV-1 antigens in both neonate groups. Cytokine dosage
in the supernatants of these polyclonally activated T cell
cultures demonstrated that, while IL-10 was the dominant
cytokine produced in G1, Th17-related cytokines were
significantly higher in G2 neonates. The higher Th17
phenotype tendency in G2 was related to high production of
IL-23 by lipopolysaccharide-activated monocyte-derived
dendritic cells from these neonates. Our results demonstrate
dimmunological disorders in uninfected neonates born from
viremic HIV-1-infected mothers that can help to explain why
some of these children have elevated risk of clinicalmorbidity
and mortality due to pathological hypersensitivity. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Genética. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HIV | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Neonates | pt_BR |
Subject | Pregnant Women | pt_BR |
Subject | IL-10 | pt_BR |
Subject | IL-17 | pt_BR |
DeCS | HIV | pt_BR |
DeCS | Citocinas | pt_BR |
DeCS | Recém-Nascido | pt_BR |
DeCS | Gestantes | pt_BR |
DeCS | Interleucina-10 | pt_BR |
DeCS | Interleucina-17 | pt_BR |