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Autor | Pimentel-Coelho, Pedro M. | |
Autor | Magalhães, Elizabeth S. | |
Autor | Lopes, Laudelino M. | |
Autor | Azevedo, Leonardo C. de | |
Autor | Santiago, Marcelo F. | |
Autor | Mendez-Otero, Rosalia | |
Fecha de acceso | 2015-02-25T13:30:58Z | |
Fecha de disponibilización | 2015-02-25T13:30:58Z | |
Fecha de publicación | 2010 | |
Referencia | PIMENTEL-COELHO, Pedro M. et al. Human cord blood transplantation in a neonatal rat model of hypoxic–ischemic brain damage: functional outcome related to neuroprotection in the striatum. Stem cells dev., Larchmont, v. 19, n. 3, 2010. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/9540 | |
Idioma | eng | pt_BR |
Editor | Mary Ann Liebert | pt_BR |
Derechos de autor | restricted access | pt_BR |
Título | Human cord blood transplantation in a neonatal rat model of hypoxic–ischemic brain damage: functional outcome related to neuroprotection in the striatum | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1089/scd.2009.0049 | |
Resumen en Inglés | Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in different models of central nervous system (CNS) damage, including stroke. We evaluated the possible therapeutic poten-tial of HUCB in P7 rats submitted to the Rice-Vannucci model of neonatal hypoxic–ischemic (HI) brain damage. Our results demonstrated that intraperitoneal transplantation of HUCB, 3 h after the HI insult, resulted in better performance in two developmental sensorimotor reflexes, in the first week after the injury. We also showed a neuroprotective effect in the striatum, and a decrease in the number of activated microglial cells in the cerebral cortex of treated animals. We suggest that HUCB transplantation might rescue striatal neurons from cell death after a neonatal HI injury resulting in better functional recovery. | pt_BR |
Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Instituto de Ciências Biomédicas. Programa de Terapia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Clínica Perinatal de Laranjeiras. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Programa de Terapia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Instituto de Ciências Biomédicas. Programa de Terapia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
DeCS | Transplante | pt_BR |
DeCS | Cordão Umbilical | pt_BR |
DeCS | Sistema Nervoso Central | pt_BR |
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