Mostrar el registro sencillo del ítem
Autor | Pacheco, Ana Paula Almeida de Souza | |
Autor | Gonçalves, Marilda de Souza | |
Fecha de acceso | 2015-03-11T17:50:18Z | |
Fecha de disponibilización | 2015-03-11T17:50:18Z | |
Fecha de publicación | 2014 | |
Referencia | PACHECO, A. P. A. S.; GONÇALVES, M. S. Klotho: its various functions and association with sickle cell disease subphenotypes. Revista Brasileira de Hematologia e Hemoterapia, v. 36, n. 6, p. 430-436, 2014 | pt_BR |
ISSN | 1516-8484 | |
URI | https://www.arca.fiocruz.br/handle/icict/9675 | |
Idioma | eng | pt_BR |
Editor | Sociedade Brasileira de Hematologia e Hemoterapia | pt_BR |
Derechos de autor | open access | pt_BR |
Título | Klotho: its various functions and association with sickle cell disease subphenotypes. | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | dx.doi.org/10.1016/j.bjhh.2014.07.022 | |
Resumen en Inglés | tThe Klotho protein, whose gene has predominant renal expression, acts in the control ofserum phosphorus and 1,25-dihydroxyvitamin D3 and regulates the function of ion chan-nels. It also participates in the mechanism of protection against oxidative stress and acts onthe vascular endothelium by inducing the production of nitric oxide. Mutations that reflectdefects in the Klotho gene expression may be implicated in the onset of osteonecrosis, pri-apism, and leg ulcers in patients with sickle cell disease, as a result of oxidative stress andendothelial impairment, important factors in the development and severity of this disease.Previous reports regarding the association of Klotho single nucleotide polymorphisms withsickle cell disease subphenotypes have found that these polymorphisms are important toidentify genetic markers of risk in these individuals and allow early and more effectivetherapeutic intervention. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Palavras clave en Inglês | Vitamin D | pt_BR |
Palavras clave en Inglês | Oxidative stress | pt_BR |
Palavras clave en Inglês | Sickle cell disease | pt_BR |
Palavras clave en Inglês | Endothelium | pt_BR |
Palavras clave en Inglês | Gene polymorphisma | pt_BR |