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VARIATION IN THE SALIVARY PEPTIDE, MAXADILAN, FROM SPECIES IN THE LUTZOMYIA LONGIPALPIS COMPLEX.
Psychodidae
Proteínas e Peptídeos Salivares/farmacologia
Vasodilatadores/farmacologia
Animais
Sequência de Bases
DNA
Proteínas de Insetos/química
Interleucina-6/biossíntese
Macrófagos Peritoneais/efeitos de drogas
Dados de Sequência Molecular
Estrutura Secundária de Proteína
Coelhos
Proteínas e Peptídeos Salivares/química
Vasodilatadores/química
Vasodilatadores/classificação
Autor
Afiliación
University of Texas Medical Branch. University Boulevard. Department of Pathology & Center for Tropical Diseases. Galveston, USA
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil
National Institute for Health and Welfare. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Hebrew University-Hadassah Medical School. Ein Kerem, Jerusalem, Israel
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Colorado State University. College of Veterinary Medicine & Biomedical Sciences. Fort Collins, CO, USA
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil
National Institute for Health and Welfare. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Hebrew University-Hadassah Medical School. Ein Kerem, Jerusalem, Israel
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Colorado State University. College of Veterinary Medicine & Biomedical Sciences. Fort Collins, CO, USA
Resumen en ingles
Maxadilan is an approximately 7kDa peptide that occurs in the saliva of the sand fly Lutzomyia longipalpis. This peptide is a potent vasodilator and may also have immunomodulatory effects related to the pathogenesis of leishmanial infections. Variation in the primary DNA and inferred amino acid sequence of maxadilan is reported. Differences were found within and among natural field populations as well as among sibling species. Extensive amino acid sequence differentiation, up to 23%, was observed among maxadilan from different populations. This is a remarkable degree of polymorphism considering the small size of this peptide. The vasodilatory activity of maxadilan was equivalent among recombinant maxadilan variants. All maxadilan variants induce interleukin-6. Predicted secondary structure and hydrophobicity plots suggest that these characteristics are conserved among variant peptides. However, profiles based on the antigenic index do differ among peptides.
DeCS
Proteínas de Insetos/farmacologiaPsychodidae
Proteínas e Peptídeos Salivares/farmacologia
Vasodilatadores/farmacologia
Animais
Sequência de Bases
DNA
Proteínas de Insetos/química
Interleucina-6/biossíntese
Macrófagos Peritoneais/efeitos de drogas
Dados de Sequência Molecular
Estrutura Secundária de Proteína
Coelhos
Proteínas e Peptídeos Salivares/química
Vasodilatadores/química
Vasodilatadores/classificação
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