Author | Titus, Richard G | |
Author | Dekrey, Gregory K | |
Author | Morris, Robin V | |
Author | Soares, Milena Botelho Pereira | |
Access date | 2015-04-07T17:24:36Z | |
Available date | 2015-04-07T17:24:36Z | |
Document date | 2001 | |
Citation | TITUS, R. G. et al. Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity, v. 69, n. 8, p. 5189-5192, 2001. | pt_BR |
ISSN | 0104-5695 | |
URI | https://www.arca.fiocruz.br/handle/icict/9911 | |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Title | Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/IAI.69.8.5189–5192.2001 | |
Abstract | Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines. | pt_BR |
Affilliation | College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA | pt_BR |
Affilliation | College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA | pt_BR |
Affilliation | College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
DeCS | Citocinas/genética | pt_BR |
DeCS | Regulação da Expressão Gênica | pt_BR |
DeCS | Interleucina-6/imunologia | pt_BR |
DeCS | Leishmania major/imunologia | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Suscetibilidade a Doenças/imunologia | pt_BR |
DeCS | Regulação para Baixo | pt_BR |
DeCS | Interleucina-6/genética | pt_BR |
DeCS | Leishmaniose Cutânea/genética | pt_BR |
DeCS | Leishmaniose Cutânea/fisiopatologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Camundongos Knockout | pt_BR |
DeCS | Células Th1/imunologia | pt_BR |