Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10023
Title: Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
Authors: Lobo, Iza Maria Fraga
Soares, Milena Botelho Pereira
Correia, Tania Maria
Freitas, Luiz Antonio Rodrigues de
Oliveira, Maria Ines
Nakatani, Maria
Martins Netto, Eduardo
Badaró, Roberto José da Silva
David, John R
Affilliation: Universidade Federal de Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal de Bahia. Salvador, BA, Brasil
Universidade Federal de Bahia. Salvador, BA, Brasil
Universidade Federal de Bahia. Salvador, BA, Brasil
Universidade Federal de Bahia. Salvador, BA, Brasil
Harvard School of Public Health. Boston, MA, USA
Abstract: Controlled heat delivered as radio waves has been used successfully in the treatment of cutaneous leishmaniasis (CL). Here we investigated whether local heat therapy has systemic effects, as measured by the modulation of cytokine production following heat therapy of CL lesions compared with antimonial (Glucantime) treatment. Patients with CL were randomly assigned into this study. Heat (50 degrees C for 30s) was applied once. The control group received Glucantime therapy for 20 d. Cytokine production by peripheral blood mononuclear cells was assayed on days 0, 14 and 28 after onset of treatment. At the end of 28 d, 75% of lesions were healing or healed in the heat therapy group and 90% in the control group (P=0.1261). There was a decrease in IFN-gamma, IL-5 and TNF-alpha levels comparing day 0 with day 28 in both groups, but no difference between the two therapy groups. In patients with only one of several lesions treated with heat therapy, the untreated lesions also healed. Local heat therapy in CL lesions leads to systemic cytokine responses similar to that induced by systemic Glucantime therapy
Keywords: Leishmaniasis Cutaneous
Leishmaniasis
Heat therapy
Cytokine
Brazil
DeCS: Antiprotozoários/uso terapêutico
Citocinas/metabolismo
Temperatura Alta/uso terapêutico
Leishmaniose Cutânea/terapia
Meglumina/uso terapêutico
Compostos Organometálicos/uso terapêutico
Adolescente
Adulto
Idoso
Feminino
Humanos
Interferon gama/metabolismo
Interleucina-10/metabolismo
Leishmaniose Cutânea/quimioterapia
Leucócitos Mononucleares/imunologia
Masculino
Meia-Idade
Resultado do Tratamento
Fator de Necrose Tumoral alfa/metabolismo
Issue Date: 2006
Publisher: Elsevier
Citation: LOBO, I. M. F. et al. Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 100, n. 7, p. 642—649, 2006.
DOI: 10.1016/j.trstmh.2005.08.011
ISSN: 0035-9203
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Lobo IMF Heat therapy for....pdf345.02 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.