Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10133
Title: Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
Authors: Lizcano, Omaira Vera
Resende, Sarah Stela
Melo, Yonne Francis Chehuan
Lacerda, Marcus Vinicius Guimarães de
Brito, Cristiana Ferreira Alves de
Zalis, Mariano Gustavo
Affilliation: Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Patologia Clínica. Laboratório de Infectologia e Parasitologia Molecular. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brasil
Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil
Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brasil
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Patologia Clínica. Laboratório de Infectologia e Parasitologia Molecular. Rio de Janeiro, RJ, Brasil
Abstract: The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the mo¬lecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax iso¬lates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
Keywords: Plasmodium vivax
chloroquine
resistance
Issue Date: 2014
Publisher: Fundação Oswaldo Cruz
Citation: LIZCANO, Omaira Vera et al. Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 109, n. 7, p. 948-951, 2014
DOI: 10.1590/0074-0276140241
ISSN: 0074-0276
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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