Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10186
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dc.contributor.authorCuba, Marília Beatriz de
dc.contributor.authorMachado, Marcus Paulo Ribeiro
dc.contributor.authorFarnesi, Thais Soares
dc.contributor.authorAlves, Angelica Cristina
dc.contributor.authorMartins, Livia Alves
dc.contributor.authorOliveira, Lucas Felipe de
dc.contributor.authorCapitelli, Caroline Santos
dc.contributor.authorLeite, Camila Ferreira
dc.contributor.authorSilva, Marcos Vinicius
dc.contributor.authorMachado, Juliana Reis
dc.contributor.authorKappel, Henrique Borges
dc.contributor.authorCampos, Helioswilton Sales de
dc.contributor.authorPaiva, Luciano
dc.contributor.authorGomes, Natália Lins da Silva
dc.contributor.authorFaleiros, Ana Carolina Guimarães
dc.contributor.authorBritto, Constança Felicia de Paoli de Carvalho
dc.contributor.authorSavino, Wilson
dc.contributor.authorMoreira, Otacílio Cruz
dc.contributor.authorRodrigues Jr., Virmondes
dc.contributor.authorMontano, Nicola
dc.contributor.authorSilva, Eliane Lages
dc.contributor.authorRamirez, Luis Eduardo
dc.contributor.authorSilva, Valdo José Dias da
dc.date.accessioned2015-05-04T16:34:37Z
dc.date.available2015-05-04T16:34:37Z
dc.date.issued2014
dc.identifier.citationCUBA, Marília Beatriz de; et al. Effects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice. Mediators of Inflammation, v.2014, 13p., 2014.
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/10186
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subject.otherDoença de Chagas
dc.subject.otherTrypanosoma cruzi
dc.subject.otherCamundongos
dc.subject.otherBrometo de Piridostigmina
dc.titleEffects of Cholinergic Stimulation with Pyridostigmine Bromide on Chronic Chagasic Cardiomyopathic Mice
dc.typeArticle
dc.identifier.doi10.1155/2014/475946
dc.description.abstractenThe aim of the present study was to assess the effects of an anticholinesterase agent, pyridostigmine bromide (Pyrido), on experimental chronic Chagas heart disease in mice. To this end, male C57BL/6J mice noninfected (control:Con) or chronically infected (5 months) with Trypanosoma cruzi (chagasic:Chg) were treated or not (NT) with Pyrido for one month. At the end of this period, electrocardiogram (ECG); cardiac autonomic function; heart histopathology; serum cytokines; and the presence of blood and tissue parasites by means of immunohistochemistry and PCR were assessed. In NT-Chg mice, significant changes in the electrocardiographic, autonomic, and cardiac histopathological profiles were observed confirming a chronic inflammatory response. Treatment with Pyrido in Chagasic mice caused a significant reduction of myocardial inflammatory infiltration, fibrosis, and hypertrophy, which was accompanied by a decrease in serum levels of IFN𝛾 with no change in IL-10 levels, suggesting a shift of immune response toward an anti-inflammatory profile. Lower nondifferent numbers of parasite DNA copies were observed in both treated and nontreated chagasic mice. In conclusion, our findings confirmthe marked neuroimmunomodulatory role played by the parasympathetic autonomic nervous systemin the evolution of the inflammatory-immune response to T. cruzi during experimental chronic Chagas heart disease in mice.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversity of Milan. L Sacco Hospital. Department of Clinical Sciences, Internal Medicine II. Milan, Italy.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.creator.affilliationUniversidade Federal do Triângulo Mineiro. Instituto de Ciências Biológicas e Naturais. Uberaba, MG, Brasil.
dc.subject.enChagas disease
dc.subject.enTrypanosoma cruzi
dc.subject.enPyridostigmine Bromide
dc.subject.enCholinergic
dc.subject.esTrypanosoma cruzi
dc.subject.esRatones
dc.subject.decsCamundongos
dc.subject.decsColinérgicos
dc.subject.decsBrometo de Piridostigmina
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