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INFLUENCE OF KIR GENES AND THEIR HLA LIGANDS IN THE PATHOGENESIS OF LEPROSY IN A HYPERENDEMIC POPULATION OF RONDONÓPOLIS, SOUTHERN BRAZIL
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Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil.
Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.
Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil.
Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.
Pontifícia Universidade Católica do Paraná. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Instituto Lauro de Souza Lima. Bauru, SP, Brasil.
Universidade Estadual de Maringá. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil.
Abstract
Background: The objective of this study was to investigate the association between KIR genes and the
immunopathogenesis of leprosy.
Methods: The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and
413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher’s exact test and stepwise
multivariate analysis.
Results: There was a higher frequency of activating KIR genes (KIR2DS1, 2DS2 and 3DS1) together with their HLA
ligands in the tuberculoid (TT) group as compared to the lepromatous leprosy (LL) group. KIR2DL2/2DL2-C1 was
more frequent in the patient, TT and LL groups than in the control group. Borderline patients presented a higher
frequency of inhibitory pairs when compared to the control group, and a higher frequency of activating pairs as
compared to the LL group. Multivariate analysis confirmed the associations and demonstrated that being a female
is a protective factor against the development of the disease per se and the more severe clinical form.
Conclusions: This study showed that activating and inhibitory KIR genes may influence the development of
leprosy – in particular, activating genes may protect against the more aggressive form of the disease – thereby
demonstrating the role of NK cells in the immunopathology of the disease.
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