Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10574
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dc.contributor.authorCosta, Emmanoel Vilaça
dc.contributor.authorMenezes, Leociley Rocha Alencar
dc.contributor.authorRocha, Suellen L. A
dc.contributor.authorBaliza, Ingrid Rayssa Souza
dc.contributor.authorDias, Rosane Borges
dc.contributor.authorRocha, Clarissa Araujo Gurgel
dc.contributor.authorSoares, Milena Botelho Pereira
dc.contributor.authorBezerra, Daniel Pereira
dc.date.accessioned2015-05-27T18:24:38Z
dc.date.available2015-05-27T18:24:38Z
dc.date.issued2014
dc.identifier.citationCOSTA, E. V. et al. Antitumor properties of the leaf essential oil of Zornia brasiliensis. Planta Médica, 2015
dc.identifier.issn0032‑0943
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/10574
dc.language.isoeng
dc.publisherVerlag KG Stuttgart
dc.rightsopen access
dc.titleAntitumor Properties of the Leaf Essential Oil of Zornia brasiliensis
dc.typeArticle
dc.identifier.doi10.1055/s-0035-1545842
dc.description.abstractenZornia brasiliensis, popularly known as “urinária”, “urinana”, and “carrapicho”, is a medicinal plant used in Brazilian northeast folk medicine as a diuretic and against venereal diseases. The aim of this study was to investigate the chemical composition and antitumor potential of the leaf essential oil of Z. brasiliensis. The essential oil was obtained by hydrodistillation using a Clevenger-type apparatus and analyzed by GC‑MS and GC‑FID. Its composition was characterized by the presence of trans-nerolidol, germacrene D, trans-caryophyllene, α-humulene, and farnesene as major constituents. In vitro cytotoxicity of the essential oil and some of its major constituents (trans-nerolidol, trans-caryophyllene, and α-humulene) was evaluated for tumor cell lines from different histotypes using the Alamar blue assay. The essential oil, but not the constituents tested, presented promising cytotoxicity. Furthermore, mice inoculated with B16-F10 mouse melanoma were used to confirm its in vivo effectiveness. An in vivo antitumor study showed tumor growth inhibition rates of 1.68–38.61% (50 and 100 mg/kg, respectively). In conclusion, the leaf essential oil of Z. brasiliensis presents trans-nerolidol, germacrene D, trans-caryophyllene, α-humulene, and farnesene as major constituents and is able to inhibit cell proliferation in cultures as well as in tumor growth in mice.
dc.creator.affilliationFederal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil / Federal University of Sergipe. Department of Chemistry. Itabaiana, SE, Brasil
dc.creator.affilliationFederal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Propedeutics. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.enZornia brasiliensis
dc.subject.enFabaceae
dc.subject.enEssential oil
dc.subject.enCytotoxicity
dc.subject.enB16‑F10
Appears in Collections:BA - IGM - Artigos de Periódicos

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