Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10628
Title: D-serine prevents cognitive deficits induced by acute stress
Authors: Guercio, G. D
Bevictori, L
Lopes, C. Vargas
Madeira, C
Oliveira, A
Carvalho, V. F
d`Avila, J. C
Panizzutti, R
Affilliation: Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.
Abstract: Increasing evidence indicates that acute stress disrupts cognitive functions mediated by glutamate- NMDA receptors, although the mechanisms are not fully understood. Here we investigated whether Dserine and glycine, the endogenous co-agonists of the NMDA receptor, are regulated by acute stress. We studied the biochemical and behavioral effects of acute restraint stress in C57BL/6 mice. Acute restraint stress decreased D-serine levels in the prefrontal cortex and glycine levels in the hippocampus. Behaviorally, acute stress impaired memory consolidation in the object recognition task and prepulse inhibition of the startle response. Importantly, D-serine administration (1 g/kg, i.p.) prevented both stressinduced impairments. Taken together, our results show for the first time an interplay between stress and D-serine and warrant further research on the role of D-serine in stress-related disorders.
Keywords: D-serine
Stress
NMDA receptor
Prepulse inhibition
Serine racemase
Object recognition task
Cognition
keywords: Estresse
DeCS: Inibição Pré-Pulso
Cognição
Serina
Issue Date: 2014
Publisher: Elsevier
Citation: GUERCIO, G. D. et al. D-serine prevents cognitive deficits induced by acute stress. Neuropharmacology, v.86, p.1-8, 2014.
DOI: 10.1016/j.neuropharm.2014.06.021
ISSN: 0028-3908
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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