Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10700
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dc.contributor.authorPires, Renata Cássia
dc.contributor.authorBoité, Mariana C
dc.contributor.authorD`Andrea, Paulo S
dc.contributor.authorHerrera, Heitor M
dc.contributor.authorCupolillo, Elisa
dc.contributor.authorJansen, Ana Maria
dc.contributor.authorRoque, André Luiz R
dc.date.accessioned2015-06-08T14:01:52Z
dc.date.available2015-06-08T14:01:52Z
dc.date.issued2014
dc.identifier.citationPIRES, Renata Cássia et al. Distinct Leishmania Species Infecting Wild Caviomorph Rodents (Rodentia: Hystricognathi) from Brazil. PLOS Neglected Tropical Diseases, v.8, n.12, 8p, 2014.
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/10700
dc.language.isoeng
dc.publisherPlos One
dc.rightsopen access
dc.subject.otherBrasil
dc.titleDistinct Leishmania Species Infecting Wild Caviomorph Rodents (Rodentia: Hystricognathi) from Brazil
dc.typeArticle
dc.identifier.doi10.1371/journal.pntd.0003389
dc.description.abstractenLeishmaniasis is a major public health problem expanding in Brazil and one of the reasons is that we still have poor knowledge of some aspects of the biology and epidemiology of Leishmania species, including the role of wild mammals. Caviomorph rodents, some of the oldest Leishmania spp. hosts, are widely dispersed in Brazil and reported as potential reservoirs of Leishmania parasites. Spleen fragments of 373 brazilian caviomorph rodents from 20 species were investigated for Leishmania infection. The molecular algorithm proposed to diagnose the infection associate the sensitivity of a molecular target with multiple copies with the specificity of another marker with discriminatory taxonomic ability between species. These demonstrated their usefulness in identifying most of the parasite species infecting the rodents, including the description of species in previously unknown hosts and in areas not previously included in their known distribution, such as L. shawi in Thrichomys inermis from Northeastern Brazil and L. naiffi in T. fosteri from Western Brazil. Although the percent of infection by molecular diagnosis was 4.6%, the serology demonstrated that about 51% of them had been exposed to Leishmania parasites pointing that caviomorph rodents are inserted in enzootic cycles of Leishmania, to a higher extent than currently recognized.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationUniversidade Católica Dom Bosco. Campo Grande, MS, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
dc.subject.enLeishmania
dc.subject.enRodents
dc.subject.enBrazil
dc.subject.enCaviomorph Rodents
dc.subject.decsRoedores
dc.subject.decsLeishmania
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