Author | Paula, Adelzon Assis de | |
Author | Schechter, Mauro | |
Author | Tuboi, Suely Hiromi | |
Author | José Claudio, Faulhaber | |
Author | Luz, Paula Mendes | |
Author | Santos, Valdiléa Gonçalves Veloso dos | |
Author | Moreira, Ronaldo Ismério | |
Author | Grinsztejn, Beatriz | |
Author | Harrison, Lee H. | |
Author | Pacheco, Antonio Guilherme Fonseca | |
Access date | 2015-06-08T15:56:26Z | |
Available date | 2015-06-08T15:56:26Z | |
Document date | 2014 | |
Citation | PAULA, Adelzon Assis de et al. Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data. Plos One, v. 9, n. 4, p. 1-5, Apr. 2014. | pt_BR |
ISSN | 1932-6203 | |
URI | https://www.arca.fiocruz.br/handle/icict/10733 | |
Sponsorship | FAPERJ, CNPq, Capes, GlaxoSmithKline | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0094636 | |
Abstract | Introduction: After antiretroviral therapy (ART) became available, there was a decline in the number of deaths in persons infected with HIV. Thereafter, there was a decrease in the proportion of deaths attributed to opportunistic infections and an increase in the proportion of deaths attributed to chronic comorbidities. Herein we extend previous observations from a nationwide survey on temporal trends in causes of death in HIV-infected patients in Brazil. Methods: We describe temporal trends in causes of death among adults who had HIV/AIDS listed in the death certificate to those who did not. All death certificates issued in Brazil from 1999 to 2011 and listed in the national mortality database were
included. Generalized linear mixed-effects logistic models were used to study temporal trends in proportions. Results: In the HIV-infected population, there was an annual adjusted average increase of 6.0%, 12.0%, 4.0% and 4.1% for cancer, external causes, cardiovascular diseases (CVD) and diabetes mellitus (DM), respectively, compared to 3.0%, 4.0%, 1.0% and 3.9%, in the non-HIV group. For tuberculosis (TB), there was an adjusted average increase of 0.3%/year and a decrease of 3.0%/year in the HIV and the non-HIV groups, respectively. Compared to 1999, the odds ratio (OR) for cancer, external causes, CVD, DM, or TB in the HIV group were, respectively, 2.31, 4.17, 1.76, 2.27 and 1.02, while for the non-HIV group, the corresponding OR were 1.31, 1.63, 1.14, 1.62 and 0.67. Interactions between year as a continuous or categorical variable and HIV were significant (p,0.001) for all conditions, except for DM when year was considered as a continuous variable (p = 0.76). Conclusions: Non HIV-related co-morbidities continue to increase more rapidly as causes of death among HIV-infected individuals than in those without HIV infection, highlighting the need for targeting prevention measures and surveillance for chronic diseases among those patients. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Escola São Francisco de Assis. Projeto Praça Onze. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | GlaxoSmithKline. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Matemática e Estatística. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of Pittsburgh. Graduate School of Public Health and School of Medicine. Infectious Diseases Epidemiology Research Unit. Pittsburgh, PA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HIV | pt_BR |
Subject | Antiretroviral therapy | pt_BR |
Subject | AIDS-related opportunistic infections | pt_BR |
Subject | Brazil/ethnology | pt_BR |
Subject | Highly active | pt_BR |
DeCS | HIV | pt_BR |
DeCS | Terapia antirretroviral de alta atividade | pt_BR |
DeCS | Infecções oportunistas relacionadas com a AIDS | pt_BR |
DeCS | Brasil/etnologia | pt_BR |
e-ISSN | 1932-6203 | |