| Author | Frydman, Ilana | |
| Author | Brasil, Pedro Emmanuel Alvarenga Americano do | |
| Author | Torres, Albina Rodrigues | |
| Author | Shavitt, Roseli Gedanke | |
| Author | Ferrão, Ygor Arzeno | |
| Author | Rosário, Maria Conceição do | |
| Author | Miguel, Euripedes Constantino | |
| Author | Fontenelle, Leonardo Ferreira | |
| Access date | 2015-06-15T17:41:03Z | |
| Available date | 2015-06-15T17:41:03Z | |
| Document date | 2014 | |
| Citation | FRYDMAN, Ilana et al. Late-onset obsessive-compulsive disorder: risk factors and correlates. Journal of Psychiatric Research, v. 49, p. 68-74, 2014. | pt_BR |
| ISSN | 0022-3956 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10848 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Late-onset obsessive-compulsive disorder: risk factors and correlates | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.jpsychires.2013.10.021 | |
| Abstract | Background: While a great amount of attention has been paid to early-onset obsessive-compulsive
disorder (OCD), there is a dearth of studies on patients showing OCD for the first time at later stages of
life. In this study, we aimed at determining possible risk factors/correlates for OCD onset at or after age
40, here termed late-onset OCD.
Method: A series of models including several potential variables associated with late onset OCD were
tested using a monolayer neural network. To this regard, data from the Brazilian Research Consortium of
Obsessive-Compulsive Spectrum Disorders (CTOC) (n ¼ 1001) was employed. For the purposes of this
study, we considered a diagnosis of late onset OCD to be present whenever distress and interference
associated with OCD symptoms emerged at or after age 40. Different nested models were compared
through the Akaike Criteria keeping the variables with p value 0.05.
Results: Late-onset OCD occurred in 8.6% of the sample. A model including female sex, a history of
chronic (>10 years) subclinical obsessive-compulsive symptoms, the co-occurrence of posttraumatic
stress disorder (PTSD) after age 40, and a history of recent pregnancy in self or significant others was able
to explain a sizeable proportion of late-onset OCD. The general performance of this model, represented
by the Maximum Likelihood R2, was 29.4%.
Conclusion: Our results suggest that late-onset OCD is more likely to occur in females, in individuals with
long periods of subclinical obsessive-compulsive symptoms, and in association with a major traumatic
event occurring after age 40 and a history of recent pregnancy in self or in significant others. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Psiquiatria. Programa de Pesquisa em Ansiedade e Depressão. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil / Instituto de Psiquiatria. Programa de Pesquisa em Ansiedade e Depressão. Rio de Janeiro, RJ, Brasil / Instituto D'Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Neurologia, Psicologia e Psiquiatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Departamento de Psiquiatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de Porto Alegre. Departamento de Psiquiatria. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Departamento de Psiquiatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Departamento de Psiquiatria. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Psiquiatria. Programa de Pesquisa em Ansiedade e Depressão. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Instituto de Saúde da Comunidade. Departamento de Psiquiatria e Saúde Mental. Niterói, RJ, Brasil / Instituto D'Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Obsessive-Compulsive Disorder | pt_BR |
| Subject | Phenotype | pt_BR |
| Subject | Statistical analysis | pt_BR |
| Subject | Post-traumatic stress disorders | pt_BR |
| DeCS | Transtorno Obsessivo-Compulsivo | pt_BR |
| DeCS | Fenótipo | pt_BR |
| DeCS | Análise estatística | pt_BR |
| DeCS | Transtornos de estresse pós-traumáticos | pt_BR |
| e-ISSN | 1879-1379 | |
