Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10877
Title: Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network)
Authors: Picot, Valentina Sanchez
Bénet, Thomas
Messaoudi, Melina
Telles, Jean-Nöel
Chou, Monidarin
Eap, Tekchheng
Wang, Jianwei
Shen, Kunling
Pape, Jean-William
Rouzier, Vanessa
Awasthi, Shally
Pandey, Nitin
Bavdekar, Ashish
Sanghvi, Sonali
Robinson, Annick
Contamin, Bénédicte
Hoffmann, Jonathan
Sylla, Maryam
Diallo, Souleymane
Nymadawa, Pagbajabyn
Dash-Yandag, Budragchaagiin
Russomando, Graciela
Basualdo, Wilma
Siqueira, Marilda M
Barreto, Patricia
Komurian-Pradel, Florence
Vernet, Guy
Endtz, Hubert
Vanhems, Philippe
Baccalà, Gláucia Paranhos
Affilliation: Fondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.
Hospices Civils de Lyon. Edouard Herriot Hospital. Infection Control and Epidemiology Unit. Lyon, Grance / Universit of Lyon 1, Epidemiology and Public Health Unit. Lyon, France.
Fondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.
Fondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.
University of Health Sciences. Faculty of Pharmacy. Phnom Penh, Cambodia.
National Pediatric Hospital. Department of Pneumology. Phnom Penh, Cambodia.
MOH Key Laboratory of Systems Biology of Pathogens. Dr. Christophe Mérieux Laboratory. Fondation Mérieux. Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College. Beijing, China.
Capital Medical University. Key Laboratory of Major Diseases in Children. National Key Discipline of Pediatrics. Ministry of Education. Beijing Pediatric Research Institute. Beijing Children’s Hospital. Capital Medical University, Beijing, China.
GHESKIO (Groupe Haïtien d’Etude du Sarcome de Kaposi et des Infections Opportunistes) Centers. Port au Prince, Haiti.
GHESKIO (Groupe Haïtien d’Etude du Sarcome de Kaposi et des Infections Opportunistes) Centers. Port au Prince, Haiti.
Chatrapati Shahuji Maharaj University. Lucknow, India.
Chatrapati Shahuji Maharaj University. Lucknow, India.
KEM Hospital Research Center. Pune, India.
KEM Hospital Research Center. Pune, India.
Hôpital Femme-Mère-Enfant. Antananarivo, Madagascar.
Fondation Mérieux. Centre d’Infectiologie Charles Mérieux (CICM); Antananarivo, Madagascar.
Fondation Mérieux. Centre d’Infectiologie Charles Mérieux (CICM); Antananarivo, Madagascar.
Gabriel Touré Hospital. Bamako, Mali.
Centre d`Infectiologie Charles Mérieux (CICM). Bamako, Mali.
Mongolian Academy of Medical Sciences. Ulaanbaatar, Mongolia.
Bayanzurkh District General Hospital. Ulaanbaatar, Mongolia.
Research Institute of health. Asuncion, Paraguay.
Hospital Pediátrico ! Niños de Acosta ¨Nu". San Lorenzo, Paraguay.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e Sarampo. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e Sarampo. Rio de Janeiro, RJ, Brasil.
Fondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.
Fondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.
Fondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.
Hospices Civils de Lyon. Edouard Herriot Hospital. Infection Control and Epidemiology Unit. Lyon, Grance / Universit of Lyon 1, Epidemiology and Public Health Unit. Lyon, France.
Fondation Mérieux. Centre Internationale Recherche en Infectiologie (CIRI). Emerging Pathogens Laboratory. Lyon, France.
Abstract: Background: Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case–control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative agents involved in pneumonia while assessing individual and microbial factors associated with the risk of severe pneumonia. Methods/design: A multicenter case–control study, based on the GABRIEL network, is ongoing. Ten study sites are located in 9 countries over 3 continents: Brazil, Cambodia, China, Haiti, India, Madagascar, Mali, Mongolia, and Paraguay. At least 1,000 incident cases and 1,000 controls will be enrolled and matched for age and date. Cases are hospitalized children <5 years with radiologically confirmed pneumonia, and the controls are children without any features suggestive of pneumonia. Respiratory specimens are collected from all enrolled subjects to identify 19 viruses and 5 bacteria. Whole blood from pneumonia cases is being tested for 3 major bacteria. S. pneumoniae-positive specimens are serotyped. Urine samples from cases only are tested for detection of antimicrobial activity. The association between procalcitonin, C-reactive protein and pathogens is being evaluated. A discovery platform will enable pathogen identification in undiagnosed samples. Discussion: This multicenter study will provide descriptive results for better understanding of pathogens responsible for pneumonia among children in developing countries. The identification of determinants related to microorganisms associated with pneumonia and its severity should facilitate treatment and prevention.
Keywords: Pneumonia
Children
Case-control
Etiology
Developing and emerging countries
DeCS: Pneumonia
Crianças
Países em Desenvolvimento
Issue Date: 2014
Publisher: BioMed Central
Citation: PICOT, Valentina Sanchez et al. Multicenter case–control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network). BMC Infectious Diseases, v.14:635, 9p, 2014.
DOI: 10.1186/s12879-014-0635-8
ISSN: 1471-2334
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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