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https://www.arca.fiocruz.br/handle/icict/10905
THE ACE INHIBITORS ENALAPRIL AND CAPTOPRIL MODULATE CYTOKINE RESPONSES IN BALB/C AND C57BL/6 NORMAL MICE AND INCREASE CD4(+)CD103(+)CD25(NEGATIVE) SPLENIC T CELL NUMBERS.
Enalapril/farmacologia
Citocinas/metabolismo
Baço/efeitos de drogas
Linfócitos T/efeitos de drogas
Inibidores da Enzima Conversora de Angiotensina/farmacologia
Animais
Antígenos CD/metabolismo
Células Cultivadas
Ensaio de Imunoadsorção Enzimática
Citometria de Fluxo
Cadeias alfa de Integrinas/metabolismo
Interleucina-10/metabolismo
Subunidade alfa de Receptor de Interleucina-2/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Especificidade da Espécie
Baço/citologia
Linfócitos T/citologia
Affilliation
Federal University of Mato Grosso. Faculty of Medicine. Department of Basic Health Science. Cuiabá, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
UCLA David Geffen School of Medicine. Division of Rheumatology. Los Angeles, CA, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
UCLA David Geffen School of Medicine. Division of Rheumatology. Los Angeles, CA, USA
Abstract
Increasing evidence implies beneficial effects of angiotensin-converting enzyme (ACE) inhibitors beyond those of their original indications to control hypertension. One of the most attractive non-hemodynamic properties of ACE inhibitors is their ability to regulate cytokine production. The mechanism(s) underlying the role of ACE inhibitors on cytokine synthesis are not well understood but they have traditionally been attributed to the inhibition of angiotensin (Ang) II formation. In fact, it has been extensively demonstrated that ACE inhibitors decrease Ang II-induced production of proinflammatory cytokines and chemokines. However, it is not well described if inhibition of endogenous Ang II generation by ACE inhibitors modulates systemic cytokine production in mice. To verify that, in this work, we investigated the effects of treatment with the ACE inhibitors enalapril and captopril on cytokine synthesis in C57Bl/6 and Balb/c mice. Our results show that enalapril up regulates IL-10 produced by splenocytes from Balb/c and C57Bl/6 mice and captopril increased it only in Balb/c mice. Furthermore, CD4(+)CD103(+) presented increased IL-10 production after enalapril treatment. Enalapril as well as captopril short-term treatment enhanced IL-2 synthesis in Balb/c mice. Besides, enhanced IL-2 and IL-10 levels correlates with increased CD4(+)CD103(+)CD25(negative) T cells numbers in spleens from enalapril-treated mice
DeCS
Captopril/farmacologiaEnalapril/farmacologia
Citocinas/metabolismo
Baço/efeitos de drogas
Linfócitos T/efeitos de drogas
Inibidores da Enzima Conversora de Angiotensina/farmacologia
Animais
Antígenos CD/metabolismo
Células Cultivadas
Ensaio de Imunoadsorção Enzimática
Citometria de Fluxo
Cadeias alfa de Integrinas/metabolismo
Interleucina-10/metabolismo
Subunidade alfa de Receptor de Interleucina-2/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Especificidade da Espécie
Baço/citologia
Linfócitos T/citologia
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