Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10969
Title: Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients.
Authors: Tarragô, Andréa Monteiro
Costa, Allyson Guimarães da
Pimentel, João Paulo Diniz
Gomes, Samara Tatielle Monteiro
Freitas, Felipe Bonfim
Lalwani, Pritesh
Araújo, Ana Ruth S. de
Victória, Flamir da Silva
Victória, Marilú Barbieri
Vallinoto, Antônio Carlos Rosário
Sadahiro, Aya
Carvalho, Andréa Teixeira
Martins Filho, Olindo Assis
Malheiro, Adriana
Affilliation: Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil/ Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil
Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil / Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
Universidade Federal do Pará. Belém, PA, Brazil
Universidade Federal do Pará. Belém, PA, Brazil
Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Universidade Federal do Pará. Belém, PA, Brazil
Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil/ Instituto Nacional de Pesquisas da Amazônia. Manaus, AM, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada Manaus, AM, Brazil/ Fundação de Hematologia e Hemoterapia do Amazonas. Manaus, AM, Brazil
Abstract: We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G1]) and 47 healthy controls. The HCV patients had higher IL-6, IL-2, IFN-γ, IL-10, and IL-17A levels than the controls. HCV G1 patients had higher IL-2 and IFN-γ levels than G2 patients. The -174IL6G>C, -308TNFαG>A, and -1082IL10A>G variants were similarly distributed in both groups. However, HCV patients with the -174IL6GC variant had higher IL-2 and IFN-γ levels than patients with the GG and CC variants. Additionally, HCV patients with the -308TNFαGG genotype had higher IL-17A levels than patients with the AG genotype, whereas patients with the -1082IL10GG variant had higher IL-6 levels than patients with the AA and AG variants. A significant proportion of HCV patients had high levels of both IL-2 and IFN-γ. The subgroup of HCV patients with the G1/IL6CG/TNFαGG association displayed the highest proportions of high producers of IL-2 and IFN-γ whereas the subgroup with the G1/TNFαGG profile showed high proportions of high producers of IL-6 and IL-17A. HCV patients with other HCV/cytokine genotype associations showed no particular cytokine profile. Our results suggest that HCV genotype G1 and IL-6 and TNF-α polymorphisms have a clinically relevant influence on serum pro-inflammatory cytokine profile (IL-2 and IFN-γ) in HCV patients.
Keywords: HCV genotype
Interleukin-10
Interleukin-6
Polymorphism
Tumor necrosis factor-α
Issue Date: 2014
Publisher: Elsevier/North-Holland.
Citation: TARRAGÔ, Andréa Monteiro et al. Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients. Hum Immunol, vol. 75, n. 11, p. 1075-83, 2014.
DOI: 10.1016/j.humimm.2014.08.198
ISSN: 0198-8859
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
2014_149.pdf635.23 kBAdobe PDF    Request a copy


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.