Author | Uehara, Aline Almeida | |
Author | Amorim, Efigenia de Lourdes Teixeira | |
Author | Ferreira, Maria de Fatima | |
Author | Andrade, Cláudia Ferreira de | |
Author | Clementino, Maysa Beatriz Mandetta | |
Author | Filippis, Ivano de | |
Author | Neves, Felipe P. G. | |
Author | Pinto, Tatiana de C. A. | |
Author | Teixeira, Lucia Martins | |
Author | Demarval, Marcia Giambiagi | |
Author | Fracalanzza, Sérgio Eduardo Longo | |
Access date | 2015-06-30T18:34:02Z | |
Available date | 2015-06-30T18:34:02Z | |
Document date | 2011 | |
Citation | Uehara, Aline Almeida et al. Molecular characterization of quinolone-resistant Neisseria gonorrhoeae isolates from Brazil. Journal of Clinical Microbiology, v. 49, n. 12, p. 4208-4212. | pt_BR |
ISSN | 0095-1137 | |
URI | https://www.arca.fiocruz.br/handle/icict/11029 | |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Neisseria gonorrhoeae | pt_BR |
Subject in Portuguese | Quinolonas | pt_BR |
Subject in Portuguese | Testes de Sensibilidade Microbiana | pt_BR |
Subject in Portuguese | Mutação de Sentido Incorreto | pt_BR |
Subject in Portuguese | Análise por Conglomerados | pt_BR |
Subject in Portuguese | Tipagem Molecular | pt_BR |
Title | Molecular characterization of quinolone-resistant Neisseria gonorrhoeae isolates from Brazil | en |
Type | Article | pt_BR |
DOI | 10.1128/jcm.01175-11 | |
Abstract | Despite the rapid spread of antibiotic resistance among gonococci worldwide, limited reports are available from Brazilian locations. In the present study, 25 quinolone-resistant Neisseria gonorrhoeae (QRNG) strains isolated in Rio de Janeiro, Brazil, were characterized by phenotypic and molecular methods, including analysis of mutations in the gyrA and parC genes. They represented 16.5% of the N. gonorrhoeae isolates obtained during a survey performed from 2006 to 2010. A trend for increasing resistance to ciprofloxacin was observed in the period investigated. The most prevalent pattern of mutation observed among QRNG isolates, Ser-91 to Phe and Asp-95 to Gly in gyrA and Ser-87 to Arg in parC, was detected in 40% of the isolates exhibiting MICs ranging from 4 to >32 mug/ml. Rare types of mutations were found in the gyrA gene (Gln-102 to His [12%] and Asp-95 to Tyr [4%]) and in the parC gene (Ser-88 to Thr [4%]). The genetic relationship of the QRNG isolates, evaluated by pulsed-field gel electrophoresis, suggested that the increase in the frequencies of the QRNG isolates in Rio de Janeiro, Brazil, may have arisen as a result of simultaneous spread of two clonal groups. The results also indicate that fluoroquinolones may no longer be used as first line antibiotics for the treatment of gonorrhea in Rio de Janeiro, and that programs for antimicrobial susceptibility surveillance of N. gonorrhoeae should also be implemented in other regions of Brazil. | en |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento Microbiologia Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Laboratório Sérgio Franco, Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Laboratório Sérgio Franco, Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento Microbiologia Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento Microbiologia Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento Microbiologia Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento Microbiologia Médica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Neisseria gonorrhoeae | en |
Subject | Quinolones | en |
Subject | Microbial Sensitivity Tests | en |
Subject | Mutation, Missense | en |
Subject | Cluster Analysis | en |
Subject | Molecular Typing | en |
DeCS | Neisseria gonorrhoeae | pt_BR |
DeCS | Quinolonas | pt_BR |
DeCS | Testes de Sensibilidade Microbiana | pt_BR |
DeCS | Mutação de Sentido Incorreto | pt_BR |
DeCS | Análise por Conglomerados | pt_BR |
DeCS | Tipagem Molecular | pt_BR |