Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/11209
Title: Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
Authors: Rodrigues, Ana Carolina B. C
Bomfim, Larissa Mendes
Neves, Sara P
Menezes, Leociley Rocha Alencar
Dias, Rosane Borges
Soares, Milena Botelho Pereira
Prata, Ana Paula N
Rocha, Clarissa Araújo Gurgel
Costa, Emmanoel Vilaça
Bezerra, Daniel Pereira
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Sergipe. Department of Chemistry. São Cristovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Federal University of Sergipe. Department of Biology. São Cristovão, SE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Propedêutica. Salvador, BA, Brasil
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Duguetia gardneriana, popularly known in the Brazilian northeast as “jaquinha”, is a species belonging to the family Annonaceae. The aim of this work was to assess the chemical composition and antitumor properties of the essential oil from the leaves of D. gardneriana in experimental models. The chemical composition of the essential oil was analyzed via gas chromatography-flame ionization detector and gas chromatography-mass spectrometry. In vitro cytotoxic activity was determined in cultured tumor cells, and in vivo antitumor activity was assessed in B16-F10-bearing mice. The identified compounds were β-bisabolene (80.99%), elemicin (8.04%), germacrene D (4.15%), and cyperene (2.82%). The essential oil exhibited a cytotoxic effect, with IC50 values of 16.89, 19.16, 13.08, and 19.33 μg/mL being obtained for B16-F10, HepG2, HL-60, and K562 cell lines, respectively. On the other hand, β-bisabolene was inactive in all of the tested tumor cell lines (showing IC50 values greater than 25 μg/ mL). The in vivo analysis revealed tumor growth inhibition rates of 5.37–37.52% at doses of 40 and 80mg/kg/day, respectively. Herein, the essential oil from the leaves of D. gardneriana presented β-bisabolene as the major constituent and showed cytotoxic and antitumor potential.
Keywords: Duguetia Gardneriana
Annonaceae
Essential oil
Cytotoxic
Antitumor
Issue Date: 2015
Publisher: Georg Thieme Verlag
Citation: RODRIGUES, A. C. B. C et al Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana. Planta Médica jun 2015
DOI: 10.1055/s-0035-1563130
ISSN: 0032-0943
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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