| Author | Pinheiro, Melina de Barros | |
| Author | Carvalho, Maria das Graças | |
| Author | Martins Filho, Olindo Assis | |
| Author | Freitas, Letícia Gonçalves | |
| Author | Godoi, Lara Carvalho | |
| Author | Alpoim, Patrícia Nessralla | |
| Author | Gomes, Karina Braga | |
| Author | Dusse, Luci Maria Sant' Ana | |
| Access date | 2015-07-17T14:11:41Z | |
| Available date | 2015-07-17T14:11:41Z | |
| Document date | 2014 | |
| Citation | PINHEIRO, Melina Barros et al. Severe preeclampsia: are hemostatic and inflammatory parameters associated?Clin Chim Acta, vol. 427, p. 65-70, 2014 | pt_BR |
| ISSN | 0009-8981 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11391 | |
| Language | eng | pt_BR |
| Publisher | Elsevier B.V. | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Severe preeclampsia: are hemostatic and inflammatory parameters associated? | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.cca.2013.09.050 | |
| Abstract | Background: Preeclampsia (PE) is characterized by hypertension and proteinuria. A predisposition to endothelial dysfunction, which may trigger abnormal activation of the hemostatic and/or inflammatory systems, is thought to play a crucial part in pathogenesis of PE. We investigated the relationship between hemostatic and inflammatory parameters in women with severe PE.
Methods: D-Dimer, PAI-1, IL-8, IL-6, TNF-α, andIFN-γ concentrationswere measured in 59 pregnant women with severe PE (sPE), 49 normotensive pregnant and 48 non-pregnant women.
Results: D-Dimer and PAI-1 were higher in women with sPE compared to normotensive pregnant and nonpregnantwomen. IL-8, IL-6, and IFN-γ alsowere higher in womenwith sPE compared to normotensive pregnant women. However, only IL-6 and IFN-γ were higher in women with sPE compared to non-pregnant women. Moreover, D-Dimer and PAI-1 showed an elevated area under ROC curve proving to be excellent for discriminating sPE. Correlation analysis showed a weak correlation between D-Dimer and IL-8 and between PAI-1 and IFN-γ in sPE.
Conclusion: D-Di and PAI-1 concentrations showed to be an important tool for monitoring sPE. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento Clinico e Toxoxologico. Belo Horizonte, MG, Brazil/Universidade Federal de São João Del Rei. Escola de Medicina. São João Del Rey. MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento Clinico e Toxoxologico. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Osvaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento Clinico e Toxoxologico. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento Clinico e Toxoxologico. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento Clinico e Toxoxologico. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento Clinico e Toxoxologico. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento Clinico e Toxoxologico. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Preeclampsia | pt_BR |
| Subject | D-Dimer | pt_BR |
| Subject | PAI-1 | pt_BR |
| Subject | Inflammatory cytokines | pt_BR |
