Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/11947
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dc.contributor.authorTuretz, Meredith L
dc.contributor.authorMachado, Paulo Roberto
dc.contributor.authorKo, Albert Icksang
dc.contributor.authorAlves, Fábio
dc.contributor.authorBittencourt, Achilea Candida Lisboa
dc.contributor.authorAlmeida, Roque Pacheco de
dc.contributor.authorMobashery, Niloufar
dc.contributor.authorJohnson Junior, Warren D
dc.contributor.authorCarvalho Filho, Edgar Marcelino
dc.date.accessioned2015-10-14T18:38:38Z
dc.date.available2015-10-14T18:38:38Z
dc.date.issued2002
dc.identifier.citationTURETZ, M. L. et al. Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil. Journal of Infectious Diseases, v. 186, n. 12, p. 1829-1834, 2002.
dc.identifier.issn0022-1899
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/11947
dc.language.isoeng
dc.publisherUniversity of Chicago, Press
dc.rightsopen access
dc.titleDisseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil.
dc.typeArticle
dc.description.abstractenDuring the past decade, there has been an increase in the number of patients with disseminated leishmaniasis (DL), which is characterized by a large number of acneiform and papular skin lesions, with very few or no parasites in the skin tissue. The present report describes 42 cases of DL identified between 1992 and 1998 in an area where Leishmania braziliensis transmission is endemic; 8 of the patients were prospectively diagnosed. In a contrast to localized cutaneous leishmaniasis (LCL), acquisition of DL was associated with age >19 years (P<.05), male sex (P<.05), and agricultural occupation (P<.001). Patients with DL presented with 10-300 lesions that were a mixture of acneiform, papular, nodular, and ulcerated types. Twelve (29%) of 42 patients had mucosal involvement. Patients with DL had lower levels of interferon-gamma (P<.05) and tumor necrosis factor-alpha (P<.05) production, compared with patients with LCL. DL is an emerging clinical distinct form of leishmaniasis associated with agricultural activities and host immunological response
dc.creator.affilliationCornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationCornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationCornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / University of Maryland. Department of Internal Medicine. Baltimore, MD
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
dc.creator.affilliationCornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / University of Maryland. Department of Internal Medicine. Baltimore, MD
dc.creator.affilliationCornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY
dc.creator.affilliationUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
dc.subject.decsLeishmania braziliensis
dc.subject.decsLeishmaniose Tegumentar Difusa/epidemiologia
dc.subject.decsAdulto
dc.subject.decsIdoso
dc.subject.decsAgricultura
dc.subject.decsAnimais
dc.subject.decsBrasil/epidemiologia
dc.subject.decsFeminino
dc.subject.decsHumanos
dc.subject.decsInterferon gama/biossíntese
dc.subject.decsLeishmaniose Tegumentar Difusa/diagnóstico
dc.subject.decsLeishmaniose Mucocutânea/diagnóstico
dc.subject.decsLeucócitos Mononucleares/metabolismo
dc.subject.decsMasculino
dc.subject.decsMeia-Idade
dc.subject.decsMembrana Mucosa/patologia
dc.subject.decsPrevalência
dc.subject.decsFatores de Risco
dc.subject.decsPele/patologia
dc.subject.decsFator de Necrose Tumoral alfa/biossíntese
Appears in Collections:BA - IGM - Artigos de Periódicos

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