| Author | Kuperman, Nina de Siqueira | |
| Author | Russomano, Fábio Bastos | |
| Author | Melo, Yara Lucia Mendes Furtado de | |
| Author | Gomes Junior, Saint Clair dos Santos | |
| Access date | 2015-10-20T12:25:44Z | |
| Document date | 2015 | |
| Citation | KUPERMAN, Nina de Siqueira et al. Preinvasive and invasive disease in women with cytological diagnosis of high-grade lesion and high-grade lesion cannot exclude microinvasion. BMC Women's Health, London, v. 15, n. 81, p. 1-6, 2015. | pt_BR |
| ISSN | 1472-6874 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11998 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | pt_BR |
| Title | Preinvasive and invasive disease in women with cytological diagnosis of high-grade lesion and high-grade lesion cannot exclude microinvasion | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s12905-015-0239-5 | |
| Abstract | Background: Cervical cancer is the third most common cancer in Brazil and has a high potential for prevention and cure. The prevalence of invasive and preinvasive disease in women with cytological diagnosis of high-grade lesion – cannot exclude microinvasion (HSIL-micro) is not known. Methods: This cross-sectional study used a cytology lab database to identify women with HSIL-micro and HSIL referred to two colposcopic units from June 2006 to December 2012. For each woman with HSIL-micro, four women with cytologic diagnosis of HSIL who met the inclusion criteria were identified. Data were obtained from review of medical records. Results: Forty-seven patients with report of HSIL-micro and 188 patients with report of HSIL were included. The final diagnoses revealed a frequency of preinvasive lesions of 31.9 % (15/47) and 59.6 % (112/188) in patients with HSIL-micro and HSIL, respectively, while the frequency of invasive disease was 63.8 % (30/47) and 11.7 % (22/188), respectively. The HSIL-micro group showed prevalence of preinvasive or invasive disease 6.5 times greater (95 % CI = 1.6-5.7) and, for invasive disease, 2.4 times greater (95 % CI = 1.7-3.6) than the HSIL group. Conclusion: Higher risk of preinvasive and invasive lesions in women with cytologic diagnosis of HSIL-micro reinforces recommendations for immediate investigation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Ginecologia. Clínica de Colposcopia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Departamento de Ginecologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Departamento de Pesquisa Clínica. Rio de Janeiro. | pt_BR |
| Subject | Uterine Cervical Neoplasms | pt_BR |
| Subject | Cervical Intraepithelial Neoplasia | pt_BR |
| Subject | Vaginal Smears | pt_BR |
| DeCS | Neoplasias do Colo do Útero | pt_BR |
| DeCS | Neoplasias | pt_BR |
