Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12444
Title: Blockade of CTLA 4 promotes the development of effector CD8 +T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY ESO 1.
Authors: Santos, Luara Isabela dos
Galvão Filho, Bruno
Faria, Paula Cristina de
Junqueira, Caroline
Dutra, Miriam Santos
Teixeira, Santuza Maria Ribeiro
Rodrigues, Maurício Martins
Ritter, Gerd
Bannard, Oliver
Fearon, Douglas Thomas
Antonelli, Lis Ribeiro
Gazzinelli, Ricardo Tostes
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brasil
Universidade Federal de São Paulo. Escola Paulista de Medicina. Centro de Terapia Celular e Molecular. São Paulo, SP, Brazil
Ludwig Institute for Cancer Research. New York Branch at Memorial Sloan - Kettering Cancer Center. New York, NY, USA
Howard Hughes Medical Institute, University of California. Department of Microbiology and Immunology. San Francisco, CA, USA
University of Cambridge School of Clinical Medicine. Department of Medicine. Cambridge, UK
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brasil/University of Massachusetts Medical School. Department of Medicine, Division of Infectious Diseases and Immunology. Worcester, USA
Abstract: The development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces both effector memory and effector CD8 + T lymphocytes that efficiently prevent tumor development. However, the therapeutic effect of such a vaccine is limited. We also demonstrate that blockade of Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) during vaccination enhances the frequency of NY-ESO-1-specific effector CD8 + T cells producing IFN-γ and promotes lymphocyte migration to the tumor infiltrate. As a result, therapy with CL-14-NY-ESO-1 together with anti-CTLA-4 is highly effective in controlling the development of an established melanoma
Keywords: Cancer
Immunotherapy
NY-ESO-1
Anti-CTLA-4
Trypanosoma cruzi
Issue Date: 2015
Publisher: Springer Science
Citation: SANTOS, Luara Isabela dos et al. Blockade of CTLA 4 promotes the development of effector CD8 +T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY ESO 1. Cancer Immunol Immunother., vol. 64, n. 3, p. 311-23, 2015.
DOI: 10.1007/s00262-014-1634-8.
ISSN: 1678-8060
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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