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DISTRIBUTION OF CCR5 GENOTYPES AND HLA CLASS I B ALLELES IN HIV-1 INFECTED AND UNINFECTED INJECTING DRUG USERS FROM RIO DE JANEIRO, BRAZIL
Autor
Afiliación
Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation - FIOCRUZ
Department of Health Information, Institute of Scientific and Technologic Information and Communication in Health, Oswaldo Cruz Foundation - FIOCRUZ
Department of Health Information, Institute of Scientific and Technologic Information and Communication in Health, Oswaldo Cruz Foundation - FIOCRUZ
Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation - FIOCRUZ
Department of Health Information, Institute of Scientific and Technologic Information and Communication in Health, Oswaldo Cruz Foundation - FIOCRUZ
Department of Health Information, Institute of Scientific and Technologic Information and Communication in Health, Oswaldo Cruz Foundation - FIOCRUZ
Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation - FIOCRUZ
Resumen en ingles
Host genetic factors play an important role in the HIV epidemic dynamics, and have been considered in
studies assessing susceptibility/resistance to HIV-1 infection as well as clinical evolution. Class I and
Class II HLA alleles have been associated with the heterogeneity of HIV-1 infection susceptibility, as
protective or risk factors for HIV-1 transmission. Moreover, a 32-base pair deletion in the HIV-1 CCR5
gene-coding region confers resistance to HIV-1 infection in homozygous individuals for the deleted
allele.
In this study, DNA samples from HIV-1 infected and uninfected injecting drug users (IDUs) from Rio
de Janeiro were PCR amplified to determine CCR5 genotypes based on the presence of the CCR5D32
mutation and typed for the HLA-B locus, in an attempt to assess possible associations between these
genetic factors and susceptibility/resistance to HIV-1 infection.
The distribution of CCR5 genotypes between the two IDU groups did not differ. The homozygous
mutant genotype D32/D32 was not found in this study. Except for HLA-B*45 (4.0% vs. 3.0%; p = 0.04) and
for B*51 (12.1% vs. 4.4%; p = 0.002), no statistically significant differences were made evident when
analyzing the frequencies of each HLA-B allele between Caucasian and non-Caucasian IDUs. The most
frequent HLA-B alleles were B*15; B*35; B*44 and B*51. Although some differences in the allele
frequencies could be observed between the two IDU groups, none of these was statistically significant.
Therefore, no putative association between these geneticmarkers and susceptibility/resistance to HIV-1
infection could be made evident in the present study. So far, the assessment of genetic markers among
the IDU population has been restricted to North American, European, and Asian studies and this report
represents a pioneer descriptive study of the distribution of CCR5 genotypes and HLA-B alleles in Rio de
Janeiro, Brazil
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