Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/1275
Title: Trends in HCV prevalence, risk factors and distribution of viral genotypes in injecting drug users: findings from two cross-sectional studies
Authors: Oliveira, Maria de Lourdes Aguiar
Yoshida, Clara Fumiko Tachibana
Dias, Paulo Roberto Telles Pires
Hacker, Mariana de Andrea Vilas-Boas
Oliveira, Sabrina Alberti Nóbrega de
Miguel, Juliana Custódio
Ó, Kycia Maria Rodrigues do
Bastos, Francisco Inácio Pinkusfeld Monteiro
Affilliation: National Reference Laboratory for Viral Hepatitis and National Reference Laboratory for Influenza and Exanthematic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Center for Drug Abuse Treatment and Research (NEPAD), State University of Rio de Janeiro, Rio de Janeiro, Brazil
Laboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Department of Health Information, Center for Information on Science and Technology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
Abstract: In the last decade, a declining prevalence of HCV infection has been described in injecting drug users (IDUs) in different countries. This study is the first to assess temporal trends in druginjecting patterns, HCV infection rates and viral genotype distribution in 770 Brazilian IDUs, recruited by two cross-sectional studies (1994–1997 and 1999–2001). A substantial decline in the prevalence of HCV infection was found over the years (75% in 1994 vs. 20 . 6% in 2001, P<0.001) that may be a consequence of the significant reduction in the overall frequencies of drug injection and needle-sharing, as well as the participation of IDUs in initiatives aimed at reducing drug-related harm. No trend was found in terms of viral genotype distribution. Despite the favourable scenario, preventive measures must be maintained, especially in vulnerable subgroups such as young or new injectors, where risky behaviours through direct and indirect sharing practices remain common.
Keywords: Hepatitis C
infectious disease epidemiology
injecting drug use
molecular epidemiology
Issue Date: 2009
Publisher: Cambridge University Press
Citation: Epidemiol. Infect. 137, 970–979, 2009
Description: This paper is based on data from two cross-sectional studies: Projeto Brasil, a multicentre study carried out from 1994–1997 to estimate prevalence of HIV and viral hepatitis in five Brazilian cities and the WHO Drug Injection Study Phase II – a project, coordinated and sponsored by the World Health Organization and implemented by the WHO Phase II Drug Injection Collaborative Study Group. The authors alone are responsible for the views expressed in this paper, which do not necessarily represent those of the other investigators participating in the WHO Drug Injection Study Phase II nor the views or policy of the World Health Organization. The Brazilian component of the study was sponsored by WHO, as well as by the Coordenac¸ a˜ o Geral de Laborato´ rios, National Health Foundation, SVS, Ministry of Health, Brazil and Conselho Nacional de Desenvolvimento Cientı´ - fico e Tecnolo´ gico, CNPq, Grant no. 475668/03. We are grateful to Genomic Platform-DNA Sequencing (PDTIS-Fiocruz) for DNA sequencing of samples included in this study.
DOI: 10.1017/S0950268808001970
ISSN: 14694409
Copyright: open access
Appears in Collections:ICICT - Artigos de Periódicos

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