Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13198
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dc.contributor.authorLopes, Ana Carolina Amaral
dc.contributor.authorMartins, Luciano Moura
dc.contributor.authorGatti, Maria Silvia Viccari
dc.contributor.authorReis, Christiane Moura Falavina dos
dc.contributor.authorHofer, Ernesto
dc.contributor.authorYano, Tomomasa
dc.date.accessioned2016-03-17T15:11:36Z
dc.date.available2016-03-17T15:11:36Z
dc.date.issued2015
dc.identifier.citationLOPES, Ana Carolina Amaral; et al. Diarrhea outbreak in Pernambuco, Brazil, associated with a heat-stable cytotoxic enterotoxin produced by Aeromonas caviae. Rev. Inst. Med. trop. S. Paulo, v.57, n.4, p. 349-351, July/Aug. 2015.
dc.identifier.issn1678-9946
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/13198
dc.language.isoeng
dc.publisherInstituto de Medicina Tropical de São Paulo
dc.rightsopen access
dc.titleDiarrhea outbreak in Pernambuco, Brazil, associated with a heat-stable cytotoxic enterotoxin produced by Aeromonas caviae
dc.title.alternativeO surto de diarreia em Pernambuco, Brasil é associado com uma enterotoxina citotóxica termo-estável produzida por Aeromonas caviae
dc.typeArticle
dc.identifier.doi10.1590/S0036-46652015000400013
dc.description.abstractenIn the present study enterotoxic and cytotoxic activities of twenty Aeromonas caviae strains were examined. They originated from fecal specimens of patients with acute diarrhea during an outbreak in Brazil in 2004. Culture supernatants of fourteen strains (70%) caused fluid accumulation in rabbit ileal intestinal loops and in suckling mice assays, and also showed a cytotoxic activity in Vero and Caco-2 cells. The enterotoxic and cytotoxic factors were heat-stable after culture supernatants treatment at 100 ºC. The results revealed that A. caviae strains produce a putative diarrheagenic virulence factor, a heat-stable cytotoxic enterotoxin that could be linked to the diarrhea outbreak that took place in Brazil.
dc.creator.affilliationUniversidade Estadual de Campinas. Departamento de Genética, Evolução e Bioagentes. Campinas, SP, Brasil.
dc.creator.affilliationInstituto Adolfo Lutz. Centro de Bacteriologia. Departamento de Doenças Infecciosas. São Paulo, SP, Brasil.
dc.creator.affilliationUniversidade Estadual de Campinas. Departamento de Genética, Evolução e Bioagentes. Campinas, SP, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.
dc.subject.enDiarrhea outbreak
dc.subject.enAeromonas caviae
dc.subject.enCytotoxic enterotoxin
dc.subject.enVirulence factors
dc.subject.enPernambuco
dc.subject.enBrazil
dc.subject.decsFatores de Virulência
dc.subject.decsCitotoxinas
dc.subject.decsAeromonas caviae
dc.subject.decsDiarreia
dc.subject.decsBrazil
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