| Author | Basano, Sergio de Almeida | |
| Author | Fontes, Gilberto | |
| Author | Medeiros, Jansen Fernandes | |
| Author | Camargo, Juliana Souza de Almeida Aranha | |
| Author | Vera, Luana Janaína Souza | |
| Author | Araújo, Marcos Paulo Parente | |
| Author | Parente, Maira Santiago Pires | |
| Author | Ferreira, Ricardo de Godoi Mattos | |
| Author | Crispim, Pedro di Tárique Barreto | |
| Author | Camargo, Luís Marcelo Aranha | |
| Access date | 2016-04-19T14:17:14Z | |
| Document date | 2014 | |
| Citation | MEDEIROS, J. F. et al. Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon. The American Journal of Tropical Medicine and Hygiene. v. 90, p. 1170-1175, 2014. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/13862 | pt_BR |
| Language | eng | pt_BR |
| Publisher | American Journal of Tropical Medicine and Hygiene | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Mansonella ozzardi | en |
| Subject in Portuguese | Infection | en |
| Subject in Portuguese | Ivermectin | en |
| Subject in Portuguese | Brazilian Amazon | en |
| Title | Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.4269/ajtmh.13-0410 | |
| Abstract | Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Lábrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level. | pt_BR |
| Affilliation | Secretaria de Saúde do Estado de Rondônia. Porto Velho, RO, Brazil. / Faculdade São Lucas. Departamento de Medicina. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Universidade Federal de São João Del Rei. Divinópolis, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Faculdade São Lucas. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Faculdade São Lucas. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Faculdade São Lucas. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Faculdade São Lucas. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Rondônia. Porto Velho, RO, Brazil. | pt_BR |
| Affilliation | Faculdade São Lucas. Departamento de Medicina. Porto Velho, RO, Brasil. / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brazil. | pt_BR |
| Embargo date | 2017-11-30 | |
