Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15056
Title: V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F
Authors: Morgado, Mariza Gonçalves
Sabino, Ester Cerdeira
Shpaer, Eugene G
Bongertz, Vera
Brigido, Luís Fernando de Macedo
Guimaraes, Mark Drew Crosland
Castilho, Euclides Ayres de
Castro Filho, Bernardo Galvão
Mullins, James I
Hendry, R Michael
Mayer, Allen
Affilliation: FIOCRUZ. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil / Irwin Memorial Blood Centers. San Francisco, California
Stanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, California
FIOCRUZ. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
FIOCRUZ. Instituto Oswaldo Cruz. Centro de Info para a Saude. Rio de Janeiro, RJ, Brasil / Minas Gerais University. Department of Preventive Medicine. Minas Gerais, BH, Brasil
FIOCRUZ. Instituto Oswaldo Cruz. Centro de Info para a Saude. Rio de Janeiro, RJ, Brasil
Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Stanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, California
Viral and Rickettsial Disease Laboratory. California Department of Health Services. Berkeley, California
Irwin Memorial Blood Centers. San Francisco, California
Abstract: Viral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high HIV-1 prevalence Brazilian cities of Rio de Janeiro and São Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was classified as subtype F, found recently in Brazil and in Romania (one appeared to be a B/F recombinant). Octameric sequences at the tip of the subtype B V3 loops were variable and distinct from those prevalent in North America and Europe. The GPGR motif, prevalent in North American/European strains, was found in only 8 (28.5%) sequences, whereas GWGR was found in 12 (43%) and novel sequences in 8 (28.5%). Brazilian subtype B sequences also diverged from the consensus North American/European strains over the remainder of the V3 loop. These results suggest that Brazilian HIV-1 B strains may have important antigenic differences from prototype subtype B strains currently being evaluated for use in HIV vaccines. These results should be taken into account for future vaccine programs in Brazil.
Keywords: AIDS Vaccines
Amino Acid Sequence
DNA, Viral
HIV Infections
Brazil
HIV-1
Humans
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Issue Date: 1994
Publisher: Mary Ann Liebert
Citation: MORGADO, M. G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994.
DOI: 10.1089/aid.1994.10.569
ISSN: 0889-2229
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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