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AutorOliveira, Daiana Santos de
AutorFigueira, Cláudio Pereira
AutorZhan, L
AutorPertile, Arsinoê Cristina
AutorPedra, Gabriel Ghizzi
AutorGusmão, I M
AutorWunder Junior, Elsio Augusto
AutorRodrigues, G
AutorRamos, Eduardo Antônio Gonçalves
AutorKo, Albert Icksang
AutorChilds, James E
AutorReis, Mitermayer Galvão dos
AutorCosta, Federico
Fecha de acceso2016-07-22T12:39:43Z
Fecha de disponibilización2016-07-22T12:39:43Z
Fecha de publicación2016
ReferenciaOLIVEIRA, D. S. Leptospira in breast tissue and milk of urban Norway rats (Rattus norvegicus). Epidemiology Infection, v. 144, n. 11, p. 2420-2429, 2016.pt_BR
ISSN0950-2688pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/15066
Idiomaengpt_BR
EditorCambridge University Presspt_BR
Derechos de autoropen accesspt_BR
TítuloLeptospira in breast tissue and milk of urban Norway rats (Rattus norvegicus)pt_BR
Tipo del documentoArticlept_BR
DOI10.1017/S0950268816000637
Resumen en InglésLeptospirosis is a zoonosis caused by bacteria of the genus Leptospira. The disease is globally distributed and a major public health concern. The Norway rat (Rattus norvegicus) is the main reservoir of the pathogen in urban slums of developing and developed countries. The potential routes of intra-specific leptospire transmission in rats are largely unknown. Herein, we identified pathogenic Leptospira spp. in breast tissue and milk of naturally infected rats. We examined kidney, breast tissue and milk from 24 lactating rats for the presence of leptospires using immunofluorescence, immunohistochemistry, polymerase chain reaction (PCR) and scanning electronic microscopy. All 24 rats had evidence for Leptospira in the kidneys, indicating chronic carriage. The majority of kidney-positive rats had detectable leptospires in milk (18, 75%) and breast tissue (16, 67%), as evidenced by immunofluorescence assay and immunohistochemistry. Four (17%) milk samples and two (8%) breast tissue samples were positive by quantitative real-time PCR. Scanning electron microscopy confirmed the presence of leptospires in breast tissue. No major pathological changes in breast tissue were found. This study, for the first time, identified leptospires in the milk and breast tissue of wild Norway rats, suggesting the possibility of milk-borne transmission of leptospirosis to neonates.pt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónYale School of Public Health. Department of Epidemiology of Microbial Disease. New Haven, USApt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónYale School of Public Health. Department of Epidemiology of Microbial Disease. New Haven, USApt_BR
AfiliaciónMinistério da Saúde. Secretaria Municipal de Saúde. Centro de Controle de Zoonoses. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Disease. New Haven, USApt_BR
AfiliaciónYale School of Public Health. Department of Epidemiology of Microbial Disease. New Haven, USApt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Disease. New Haven, USA / Universidade Federal da Bahia. UFBA. Faculdade de Medicina. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Disease. New Haven, USA / Universidade Federal da Bahia. UFBA. Instituto de Saúde Coletiva. Salvador, BA, Brasilpt_BR
Palavras clave en InglêsBreastfeedingpt_BR
Palavras clave en InglêsImmunofluorescencept_BR
Palavras clave en InglêsImmunohistochemistrypt_BR
Palavras clave en InglêsRattus norvegicuspt_BR
Palavras clave en InglêsScanning electronic microscopypt_BR
Palavras clave en InglêsVertical transmissionpt_BR


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