Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15194
Title: Immune serum from both susceptible and resistant strains of mice increases phagocytosis of Leishmania mexicana amazonensis by macrophages
Authors: Reis, Mitermayer Galvão dos
Roters, S B
Barral Netto, Manoel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil
Abstract: Immune sera obtained from either BALB/c mice (susceptible) at 7 weeks, or C57BL/6 mice (resistant), at 7 weeks after infection with L. m. amazonensis, were effective in increasing internalization of homologous promastigotes into starch-induced peritoneal macrophages (from both mouse strains). Both the internalization enhancing effect and the levels of anti-leishmanial antibody (ELISA) were removed from sera by absorption with heat-killed promastigotes. Sera at 1/200 dilution obtained from either mouse strain at 2 weeks after infection did not enhance parasite internalization into macrophages. The factors leading to susceptibility or resistance during leishmaniasis do not appear to be related to differences in antibody-mediated opsonic activity.
Keywords: Cutaneous leishmaniasis
Murine leishmaniasis
Leishmania
L. mexicana
Issue Date: 1987
Publisher: Elsevier
Citation: REIS, M. G., ROTERS, S. B. ; BARRAL NETTO, M. Immune serum from both susceptible and resistant strains of mice increases phagocytosis of Leishmania mexicana amazonensis by macrophages. Acta Tropica, v. 44, p. 339-342, 1987.
ISSN: 0001-706X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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