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LARVAL APPLICATION OF SODIUM CHANNEL HOMOLOGOUS DSRNA RESTORES PYRETHROID INSECTICIDE SUSCEPTIBILITY IN A RESISTANT ADULT MOSQUITO POPULATION
Bona, Ana Caroline Dalla et al. | Date Issued: 2016
Author
Bona, Ana Caroline Dalla
Chitolina, Rodrigo Faitta
Fermino, Marise Lopes
Poncio, Lisiane de Castro
Weiss, Avital
Lima, José Bento Pereira
Paldi, Nitzan
Bernardes, Emerson Soares
Henen, Jonathan
Maori, Eyal
Affilliation
Forrest Brasil Tecnologia Ltda. Curitiba, PR, Brasil.
Forrest Brasil Tecnologia Ltda. Curitiba, PR, Brasil.
Forrest Brasil Tecnologia Ltda. Curitiba, PR, Brasil.
Forrest Brasil Tecnologia Ltda. Curitiba, PR, Brasil.
Forrest Innovations Ltd. Caesarea. Israel.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores.Rio de Janeiro, RJ, Brasil.
Forrest Innovations Ltd. Caesarea. Israel.
Forrest Brasil Tecnologia Ltda. Curitiba, PR, Brasil / Nuclear Energy Research Institute. Radiopharmacy Center. São Paulo, SP, Brasil.
Forrest Innovations Ltd. Caesarea. Israel.
Forrest Innovations Ltd. Caesarea. Israel.
Abstract
Mosquitoes host and pass on to humans a variety of disease-causing pathogens such as infectious viruses and other parasitic microorganisms. The emergence and spread of insecticide resistance is threatening the effectiveness of current control measures for common mosquito vector borne diseases, such as malaria, dengue and Zika. Therefore, the emerging resistance to the widely used pyrethroid insecticides is an alarming problem for public health. Herein we demonstrated the use of RNA interference (RNAi) to increase susceptibility of adult mosquitoes to a widely used pyrethroid insecticide.
Keywords in Portuguese
Piretróides
Keywords
Insecticide resistance
Pyrethroids
Voltage-gated sodium channel
RNAi
Aedes aegypti
Mosquitoes
 
DeCS
Resistência a Inseticidas
Terapêutica com RNAi
Culicidae
Aedes
 
Publisher
BioMed Central
Citation
BONA, Ana Caroline Dalla; et al. Larval application of sodium channel homologous dsRNA restores pyrethroid insecticide susceptibility in a resistant adult mosquito population. Parasite & Vectors, v.9:397, 14p, 2016.
ISSN
1756-3305