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METHODOLOGICAL APPROACHES TO EVALUATE TERATOGENIC RISK USING BIRTH DEFECT REGISTRIES: ADVANTAGES AND DISADVANTAGES
Poletta, Fernando A. et al. | Date Issued: 2012
Author
Poletta, Fernando A.
López Camelo, Jorge S.
Gili, Juan A.
Leoncini, Emmanuele
Castilla, Eduardo E.
Mastroiacovo, Pierpaolo
Affilliation
ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at Centro de Educación Médica e Investigaciones Clínicas (CEMIC) (CONICET). Buenos Aires, Argentina / INAGEMP (Instituto Nacional de Genética Médica Populacional). Rio de Janeiro, RJ, Brasil.
ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at Centro de Educación Médica e Investigaciones Clínicas (CEMIC) (CONICET). Buenos Aires, Argentina / ECLAMC at Instituto Multidisciplinario de Biología Celular (IMBICE) (CIC-CONICET). La Plata, Argentina / INAGEMP (Instituto Nacional de Genética Médica Populacional). Rio de Janeiro, RJ, Brasil.
ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at Centro de Educación Médica e Investigaciones Clínicas (CEMIC) (CONICET). Buenos Aires, Argentina / INAGEMP (Instituto Nacional de Genética Médica Populacional). Rio de Janeiro, RJ, Brasil.
Headquarters of the International Clearinghouse for Birth Defects Surveillance and Research. Rome, Italy.
ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at Centro de Educación Méedica e Investigaciones Clínicas (CEMIC) (CONICET). Buenos Aires, Argentina / ECLAMC at Fundação Oswaldo Cruz. Instituto Oswaldo cruz. Rio de Janeiro, RJ, Brasil / INAGEMP (Instituto Nacional de Genética Médica Populacional). Rio de Janeiro, RJ, Brasil.
Headquarters of the International Clearinghouse for Birth Defects Surveillance and Research. Rome, Italy.
Abstract
Different approaches have been used in case-control studies to estimate maternal exposure to medications and the risk of birth defects. However, the performance of these approaches and how they affect the odds ratio (OR) estimates have not been evaluated using birth-defect surveillance programmes. The aim of this study was to evaluate the scope and limitations of three case-control approaches to assess the teratogenic risk of birth defects in mothers exposed to antiepileptic medications, insulin, or acetaminophen.
Keywords in Portuguese
Abordagens metodológicas
Defeitos de nascença
Risco teratogênico
 
Keywords
Birth Defect
Methodological Approaches
Teratogenic Risk
 
Publisher
Public Library Science
Citation
POLETTA, Fernando A. et al. Methodological Approaches to Evaluate Teratogenic Risk Using Birth Defect Registries: Advantages and Disadvantages. Plos One, v.7, n.10, e46626, 11p, Oct. 2012.
DOI
10.1371/journal.pone.0046626
ISSN
1932-6203