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WOMEN ARE MORE SUSCEPTIBLE TO CARIES BUT INDIVIDUALS BORN WITH CLEFTS ARE NOT
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University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
Children’s Hospital of Pittsburgh. Division of Pediatric Hematology-Oncology. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Centro de Ciências da Saúde. Departamento de Genética. Rio de Janeiro, RJ, Brasil.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
(ECLAMC) Latin American Collaborative Study of Congenital Malformations at Hospital de Area El Bolsón. Río Negro, Argentina.
(ECLAMC at CEMIC) Center for Medical Education and Clinical Research. Buenos Aires, Argentina / (CONICET) National Research Council of Argentina. Argentina / (INAGEMP-CNPq)National Institute of Population Medical Genetics. Brasil.
(ECLAMC at CEMIC) Center for Medical Education and Clinical Research. Buenos Aires, Argentina / (CONICET) National Research Council of Argentina. Argentina / (INAGEMP-CNPq)National Institute of Population Medical Genetics. Brasil / (ECLAMC at INAGEMP-CNPq) National Institute of Population Medical Genetics in CEMIC.Buenos Aires, Argentina.
(CONICET) National Research Council of Argentina. Argentina / (INAGEMP-CNPq) National Institute of Population Medical Genetics. Brasil / (ECLAMC at IMBICE ) Multidisciplinary Institute of Cellular Biology. La Plata, Argentina / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Centro de Ciências da Saúde. Departamento de Genética. Rio de Janeiro, RJ, Brasil / (INAGEMP-CNPq)National Institute of Population Medical Genetics. Brasil.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Pediatric Dentistry. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
Children’s Hospital of Pittsburgh. Division of Pediatric Hematology-Oncology. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Centro de Ciências da Saúde. Departamento de Genética. Rio de Janeiro, RJ, Brasil.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA.
(ECLAMC) Latin American Collaborative Study of Congenital Malformations at Hospital de Area El Bolsón. Río Negro, Argentina.
(ECLAMC at CEMIC) Center for Medical Education and Clinical Research. Buenos Aires, Argentina / (CONICET) National Research Council of Argentina. Argentina / (INAGEMP-CNPq)National Institute of Population Medical Genetics. Brasil.
(ECLAMC at CEMIC) Center for Medical Education and Clinical Research. Buenos Aires, Argentina / (CONICET) National Research Council of Argentina. Argentina / (INAGEMP-CNPq)National Institute of Population Medical Genetics. Brasil / (ECLAMC at INAGEMP-CNPq) National Institute of Population Medical Genetics in CEMIC.Buenos Aires, Argentina.
(CONICET) National Research Council of Argentina. Argentina / (INAGEMP-CNPq) National Institute of Population Medical Genetics. Brasil / (ECLAMC at IMBICE ) Multidisciplinary Institute of Cellular Biology. La Plata, Argentina / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Centro de Ciências da Saúde. Departamento de Genética. Rio de Janeiro, RJ, Brasil / (INAGEMP-CNPq)National Institute of Population Medical Genetics. Brasil.
University of Pittsburgh. School of Dental Medicine. Departments of Oral Biology. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Center for Dental and Craniofacial Genetics. Pittsburgh, PA, USA / University of Pittsburgh. School of Dental Medicine. Pediatric Dentistry. Pittsburgh, PA, USA.
Abstract
The identification of individuals at a higher risk of developing caries is of great interest. Isolated forms of cleft lip and palate are among the most common craniofacial congenital anomalies in humans. Historically, several reports suggest that individuals born with clefts have a higher risk for caries. Caries continues to be the most common infectious noncontagious disease worldwide and a great burden to any health system. The identification of individuals of higher susceptibility to caries is of great interest. In this paper, we assessed caries experience of 1,593 individuals from three distinct populations. The study included individuals born with clefts, their unaffected relatives, and unrelated unaffected controls that were recruited from areas with similar cultural pressures and limited access to dental care. DMFT/dmft scores were obtained, and caries experience rates were compared among the three groups in each geographic area. Individuals born with clefts did not present higher caries experience in comparison to their unaffected relatives or unrelated unaffected controls. Women tend to present higher caries rates in comparison to men. Our work provides strong evidence that individuals born with clefts are not at higher risk to caries; however, women tend to have more severe caries experience.
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